Evidence map›Paper›PMID 36589805›Full record

ReviewFrontiers in endocrinology2022

Mechanistic investigations of diabetic ocular surface diseases.

Qingjun Zhou, Lingling Yang, Qun Wang, Ya Li, Chao Wei, Lixin Xie

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06218992 (Corneal and Tear Film Changes in Chinese Patients With Type 2 Diabetes), which is not on this map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
11.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06218992 unknown statusnot on this mapstarted 2023, after this paper: background citation

Corneal and Tear Film Changes in Chinese Patients With Type 2 Diabetes: a Cross-sectional Controlled Study

TypeobservationalSponsorHe Eye HospitalRan2023 to 2024Enrolled80ConditionsDry Eye Disease, Tear Film, Corneal Nerve
3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.

  1. Pooled it
  2. Review
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  8. Fenofibrate in ophthalmology: therapeutic efficacy and mechanisms.Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques · 2026
    Review
  9. Article
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  16. Electroacupuncture regulates the P2XPurinergic signalling · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Qingjun ZhouState Key Laboratory Cultivation Base, Eye Institute of Shandong First Medical University, Qingdao, China.
Lingling YangState Key Laboratory Cultivation Base, Eye Institute of Shandong First Medical University, Qingdao, China.
Qun WangState Key Laboratory Cultivation Base, Eye Institute of Shandong First Medical University, Qingdao, China.
Ya LiState Key Laboratory Cultivation Base, Eye Institute of Shandong First Medical University, Qingdao, China.
Chao WeiState Key Laboratory Cultivation Base, Eye Institute of Shandong First Medical University, Qingdao, China.
Lixin XieState Key Laboratory Cultivation Base, Eye Institute of Shandong First Medical University, Qingdao, China.
Shandong Eye Hospital · CNShandong First Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With the global prevalence of diabetes mellitus over recent decades, more patients suffered from various diabetic complications, including diabetic ocular surface diseases that may seriously affect the quality of life and even vision sight. The major diabetic ocular surface diseases include diabetic keratopathy and dry eye. Diabetic keratopathy is characterized with the delayed corneal epithelial wound healing, reduced corneal nerve density, decreased corneal sensation and feeling of burning or dryness. Diabetic dry eye is manifested as the reduction of tear secretion accompanied with the ocular discomfort. The early clinical symptoms include dry eye and corneal nerve degeneration, suggesting the early diagnosis should be focused on the examination of confocal microscopy and dry eye symptoms. The pathogenesis of diabetic keratopathy involves the accumulation of advanced glycation end-products, impaired neurotrophic innervations and limbal stem cell function, and dysregulated growth factor signaling, and inflammation alterations. Diabetic dry eye may be associated with the abnormal mitochondrial metabolism of lacrimal gland caused by the overactivation of sympathetic nervous system. Considering the important roles of the dense innervations in the homeostatic maintenance of cornea and lacrimal gland, further studies on the neuroepithelial and neuroimmune interactions will reveal the predominant pathogenic mechanisms and develop the targeting intervention strategies of diabetic ocular surface complications.

Indexed as

Corneal DiseasesDiabetes ComplicationsDiabetes MellitusDry Eye SyndromesCorneaHumansQuality of Lifediabetic keratopathydry eyeepitheliopathylacrimal glandneuropathypathogenesis

Identifiers

PMID36589805
PMCPMC9800783
OpenAlexW4313272751

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.