Evidence map›Paper›PMID 36589698›Full record

ArticleMolecular therapy oncolytics2023

A library of cancer testis specific T cell receptors for T cell receptor gene therapy.

Marije A J de Rooij, Dennis F G Remst, Dirk M van der Steen, Anne K Wouters, Renate S Hagedoorn, Michel G D Kester, Miranda H Meeuwsen, Tassilo L A Wachsmann, Arnoud H de Ru, Peter A van Veelen and 3 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Molecular therapy oncolytics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. DNA-demethylation by DAC inducesMolecular therapy. Oncology · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Marije A J de RooijDepartment of Hematology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, the Netherlands.
Dennis F G RemstDepartment of Hematology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, the Netherlands.
Dirk M van der SteenDepartment of Hematology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, the Netherlands.
Anne K WoutersDepartment of Hematology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, the Netherlands.
Renate S HagedoornDepartment of Hematology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, the Netherlands.
Michel G D KesterDepartment of Hematology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, the Netherlands.
Miranda H MeeuwsenDepartment of Hematology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, the Netherlands.
Tassilo L A WachsmannDepartment of Hematology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, the Netherlands.
Arnoud H de RuCenter for Proteomics and Metabolics, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands.
Peter A van VeelenCenter for Proteomics and Metabolics, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands.
Els M E VerdegaalDepartment of Medical Oncology, Oncode Institute, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands.
J H Frederik FalkenburgDepartment of Hematology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, the Netherlands.
Mirjam H M HeemskerkDepartment of Hematology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, the Netherlands.
Leiden University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To increase the number of cancer patients that can be treated with T cell receptor (TCR) gene therapy, we aimed to identify a set of high-affinity cancer-specific TCRs targeting different melanoma-associated antigens (MAGEs). In this study, peptides derived from

Indexed as

Cancer Testis genesCD8+ T cellsMAGET cell receptorTCR gene therapy

Identifiers

PMID36589698
PMCPMC9792401
OpenAlexW4311765982

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.