Evidence map›Paper›PMID 36589695›Full record

ArticleAging brain2022

Cerebral Aβ deposition in an Aβ-precursor protein-transgenic rhesus monkey.

Anthony W S Chan, In Ki Cho, Chun-Xia Li, Xiaodong Zhang, Sudeep Patel, Rebecca Rusnak, Jessica Raper, Jocelyne Bachevalier, Sean P Moran, Tim Chi and 13 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging brain, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. In-silico structural analysis ofMolecular biology research communications · 2024
    Article
  7. Magnetic resonance imaging of the monkey fetal brain in utero.Investigative magnetic resonance imaging · 2022
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 1 institution in 1 country.

Anthony W S ChanEmory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
In Ki ChoEmory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Chun-Xia LiEmory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Xiaodong ZhangEmory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Sudeep PatelEmory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Rebecca RusnakEmory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Jessica RaperEmory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Jocelyne BachevalierEmory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Sean P MoranEmory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Tim ChiEmory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Katherine H CannonEmory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Carissa E HunterEmory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Ryan C MartinEmory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Hailian XiaoDepartment of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Shang-Hsun YangEmory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Sanjeev GumberEmory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
James G HerndonEmory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Rebecca F RosenEmory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
William T HuDepartment of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA.
James J LahDepartment of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Allan I LeveyDepartment of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Yoland SmithEmory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Lary C WalkerEmory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Emory University · US

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
The Goizueta Alzheimer's Disease Research CenterP30AG066511 · NIA · EMORY UNIVERSITY · PI Amy D Rodriguez · 2020 to 2026
$29.0M
The Emory Alzheimer's Disease CenterP50AG025688 · NIA · EMORY UNIVERSITY · PI WALKER, LARY C · 2005 to 2019
$25.7M
Transgenic Huntington's disease monkey resourceR24OD010930 · OD · EMORY UNIVERSITY · PI CHAN, ANTHONY WING SANG · 2012 to 2018
$6.1M
NIA NIH HHS P30 AG066511NIA NIH HHS P50 AG025688NIH HHS P51 OD011132NIH HHS R24 OD010930
6 · The paper itself

Abstract

With the ultimate goal of developing a more representative animal model of Alzheimer's disease (AD), two female amyloid-β-(Aβ) precursor protein-transgenic (APPtg) rhesus monkeys were generated by lentiviral transduction of the

Indexed as

Alzheimer’s diseaseAmyloid precursor proteinAnimal modelCerebral amyloid angiopathyTau

Identifiers

PMID36589695
PMCPMC9802652
OpenAlexW4285260795

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.