ArticleBiomedical optics express2022
Motion-tracking Brillouin microscopy for in-vivo corneal biomechanics mapping.
Article in Biomedical optics express, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Motion-Tracking Brillouin Microscopy for Keratoconus Suspect Identification: Comparison With Multimodal Corneal Imaging.American journal of ophthalmology · 2026Article
- Brillouin microscopic assessment of retinal stiffness during reactive Müller gliosis.Experimental eye research · 2026Article
- Wavelet time-frequency analysis enhances noise-resilient quantification of corneal wave velocity and natural frequency in optical coherence elastography.Biomedical optics express · 2026Article
- Quantitative assessment of the biomechanical properties of healthy human myopic corneas using Brillouin spectroscopy.BMC ophthalmology · 2026Article
- Article
- Roadmap on advances in visual and physiological optics.Journal of optics (2010) · 2025Review
- Clinical multimodal Brillouin microscopy-optical coherence elastography system for lens biomechanics.Journal of biomedical optics · 2025Article
- Three-Dimensional Mechanical Characterization of Normal, Subclinical, and Keratoconic Corneas Using Motion Tracking Brillouin Microscopy.American journal of ophthalmology · 2025Article
- Article
- Article
- Review
- In vivo measurement of the biomechanical properties of human skin with motion-corrected Brillouin microscopy.Biomedical optics express · 2024Article
- Subclinical Keratoconus Detection and Characterization Using Motion-Tracking Brillouin Microscopy.Ophthalmology · 2024Article
- Brillouin microscopy.Nature reviews. Methods primers · 2024Article
- Motion-Tracking Brillouin Microscopy Evaluation of Normal, Keratoconic, and Post-Laser Vision Correction Corneas.American journal of ophthalmology · 2023Article
- Corneal Biomechanical Measures for Glaucoma: A Clinical Approach.Bioengineering (Basel, Switzerland) · 2023Review
- Review
- Focal Weakening/Thinnest Corneal Point Proximity in Normal, Subclinical, and Keratoconic Corneas Using Motion-Tracking Brillouin Microscopy.Ophthalmology scienceArticle
- Brillouin microscopy for focal biomechanical measurements in normal and keratoconic corneas: A narrative review.Survey of ophthalmologyReview
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Corneal biomechanics play a critical role in maintaining corneal shape and thereby directly influence visual acuity. However, direct corneal biomechanical measurement in-vivo with sufficient accuracy and a high spatial resolution remains an open need. Here, we developed a three-dimensional (3D) motion-tracking Brillouin microscope for in-vivo corneal biomechanics mapping. The axial tracking utilized optical coherence tomography, which provided a tracking accuracy better than 3 µm. Meanwhile, 10 µm lateral tracking was achieved by tracking pupils with digital image processing. The 3D tracking enabled reconstruction of depth-dependent Brillouin distribution with a high spatial resolution. This superior technical performance enabled the capture of high-quality mechanical mapping in vivo even while the subject was breathing normally. Importantly, we improved Brillouin spectral measurements to achieve relative accuracy better than 0.07% verified by rubidium absorption frequencies, with 0.12% stability over 2000 seconds. These specifications finally yield the Brillouin measurement sensitivity that is required to detect ophthalmology-relevant corneal biomechanical properties.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.