Evidence map›Paper›PMID 36589578›Full record

ArticleBiomedical optics express2022

Repeatability and reciprocity of the cone optoretinogram.

R L Warner, D H Brainard, J I W Morgan

Open access · goldAbstract read
In one paragraph

Article in Biomedical optics express, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. ƒ(Cell): Software for Reproducible Analysis of Optoretinograms.Translational vision science & technology · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Optical Assessment of Photoreceptor Function Over the Macula.Translational vision science & technology · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

R L WarnerScheie Eye Institute, Department of Ophthalmology, University of Pennsylvania, Philadelphia, PA, 19104, USA.ORCID https://orcid.org/0000-0003-0704-8333
D H BrainardPsychology Department, University of Pennsylvania, Philadelphia, PA, 19104, USA.
J I W MorganScheie Eye Institute, Department of Ophthalmology, University of Pennsylvania, Philadelphia, PA, 19104, USA.ORCID https://orcid.org/0000-0002-9878-7336
Penn Presbyterian Medical Center · USCalifornia University of Pennsylvania · US

Funding

Scientific TransparencyP30EY001583 · NEI · UNIVERSITY OF PENNSYLVANIA · PI CLAIRE H MITCHELL · 1985 to 2026
$19.5M
Retinal structure, function and response to gene therapyR01EY028601 · NEI · UNIVERSITY OF PENNSYLVANIA · PI Jessica I.W. Morgan · 2018 to 2026
$3.6M
Imaging Photoreceptor FunctionR01EY030227 · NEI · UNIVERSITY OF PENNSYLVANIA · PI David H. Brainard, Jessica I.W. Morgan · 2020 to 2026
$1.8M
NEI NIH HHS P30 EY001583NEI NIH HHS R01 EY028601NEI NIH HHS R01 EY030227
6 · The paper itself

Abstract

Optoretinography has enabled noninvasive visualization of physiological changes in cone photoreceptors exposed to light. Understanding the cone optoretinogram in healthy subjects is essential for establishing it as a biomarker for cone function in disease. Here, we measure the population cone intensity optoretinogram in healthy adults, for multiple irradiance/duration combinations of visible stimuli with equal energy. We study the within and between session repeatability and reciprocity of the ORG in five healthy subjects. We find the cone optoretinogram exhibits equivalent amplitudes for equal-energy stimuli. We also find good within-subject repeatability, which allows us to show differences across the five subjects.

Identifiers

PMID36589578
PMCPMC9774868
OpenAlexW4308882085

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.