ArticleBiomedical optics express2022
Assessing and compensating for the confounding factors in Scheimpflug-based corneal densitometry.
Article in Biomedical optics express, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Influence of Room Illumination on Corneal Densitometry.Translational vision science & technology · 2026Article
- A Method for Visualizing Corneal Dynamics Through Pixel Intensity Tracking.Translational vision science & technology · 2025Article
- OCT based corneal densitometry: the confounding effect of epithelial speckle.Biomedical optics express · 2023Article
Corrections and comments
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Authors and funding
3 authors.
Funding
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Abstract
Scheimpflug-based corneal densitometry is a clinically verified method for assessing corneal transparency. Nevertheless, the estimates of corneal densitometry appear to be correlated with age and eye biometry parameters, such as the anterior chamber depth or the pupil size, and that ensues a convoluted conditional estimation problem, where it is difficult to interpret the results. This study aims at devising a methodology for compensating for such confounding factors by using, as a research platform, a commercially available Scheimpflug camera that allows exporting images in a dynamic fashion, allowing averaging the results from multiple acquisitions. Two approaches are considered, one based on appropriately normalizing the line densitometry signal and one based on image histogram equalization. Then, three parameters for describing corneal densitometry are derived including the mean value of backscatter and the scale and shape parameters of the Weibull distribution estimated in regions of interest encompassing parts of corneal stroma. The results show that, unlike the non-normalized measures, the proposed approaches lead to parameters that are not correlated with age nor the eye biometry.
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Registered trials
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