Evidence map›Paper›PMID 36589569›Full record

ArticleBiomedical optics express2022

Miniaturized structured illumination microscopy using two 3-axis MEMS micromirrors.

Peter Tinning, Mark Donnachie, Jay Christopher, Deepak Uttamchandani, Ralf Bauer

Open access · goldAbstract read
In one paragraph

Article in Biomedical optics express, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Peter TinningCentre for Microsystems and Photonics, Department of Electronic and Electrical Engineering, University of Strathclyde, 99 George Street, Glasgow, G1 1RD, UK.
Mark DonnachieCentre for Microsystems and Photonics, Department of Electronic and Electrical Engineering, University of Strathclyde, 99 George Street, Glasgow, G1 1RD, UK.
Jay ChristopherCentre for Microsystems and Photonics, Department of Electronic and Electrical Engineering, University of Strathclyde, 99 George Street, Glasgow, G1 1RD, UK.
Deepak UttamchandaniCentre for Microsystems and Photonics, Department of Electronic and Electrical Engineering, University of Strathclyde, 99 George Street, Glasgow, G1 1RD, UK.
Ralf BauerCentre for Microsystems and Photonics, Department of Electronic and Electrical Engineering, University of Strathclyde, 99 George Street, Glasgow, G1 1RD, UK.ORCID https://orcid.org/0000-0001-7927-9435
University of Strathclyde · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present the development and performance characterisation of a novel structured illumination microscope (SIM) in which the grating pattern is generated using two optical beams controlled via 2 micro-electro-mechanical system (MEMS) three-axis scanning micromirrors. The implementation of MEMS micromirrors to accurately and repeatably control angular, radial and phase positioning delivers flexible control of the fluorescence excitation illumination, with achromatic beam delivery through the same optical path, reduced spatial footprint and cost-efficient integration being further benefits. Our SIM architecture enables the direct implementation of multi-color imaging in a compact and adaptable package. The two-dimensional SIM system approach is enabled by a pair of 2 mm aperture electrostatically actuated three-axis micromirrors having static angular tilt motion along the x- and y-axes and static piston motion along the z-axis. This allows precise angular, radial and phase positioning of two optical beams, generating a fully controllable spatial interference pattern at the focal plane by adjusting the positions of the beam in the back-aperture of a microscope objective. This MEMS-SIM system was applied to fluorescent bead samples and cell specimens, and was able to obtain a variable lateral resolution improvement between 1.3 and 1.8 times the diffraction limited resolution.

Identifiers

PMID36589569
PMCPMC9774859
OpenAlexW4308731053

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.