ArticleBiomedical optics express2022
Characterizing cone spectral classification by optoretinography.
Article in Biomedical optics express, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Proto-clinical optoretinography dependence on temporal and spatial resolution.Biomedical optics express · 2026Article
- In vivo elastography of the human retina using light-evoked intrinsic actuation.bioRxiv : the preprint server for biology · 2026Article
- Optoretinography in R9AP-bradyopsia reveals the essential role of G-protein signaling in the human cone elongation response.bioRxiv : the preprint server for biology · 2026Article
- Evaluating Human Rod Photoreceptor Function Using Pixelwise Intensity-Based Optoretinography.Translational vision science & technology · 2026Article
- ƒ(Cell): Software for Reproducible Analysis of Optoretinograms.Translational vision science & technology · 2026Article
- Optoretinography reveals rapid rod photoreceptor movement upon rhodopsin activation.Light, science & applications · 2026Article
- On the physiological processes underlying optoretinography [Invited].Biomedical optics express · 2025Review
- Local variations in L/M ratio influence the detection and color naming of small spots.Journal of vision · 2025Article
- Local variations in L/M ratio influence the detection and color naming of small spots.bioRxiv : the preprint server for biology · 2025Article
- Combined optical coherence tomography and electroretinography system for imaging neurovascular coupling in the human retina.Neurophotonics · 2025Article
- The Cone Optoretinogram as a Function of Retinal Eccentricity.Photonics · 2025Article
- Novel color via stimulation of individual photoreceptors at population scale.Science advances · 2025Article
- Photopic flicker optoretinography captures the light-driven length modulation of photoreceptors during phototransduction.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Polarization optical coherence tomography optoretinography: verifying light-induced photoreceptor outer segment shrinkage and subretinal space expansion.Neurophotonics · 2025Article
- Optical Coherence Tomography Split-Spectrum Amplitude-Decorrelation Optoretinography Detects Early Central Cone Photoreceptor Dysfunction in Retinal Dystrophies.Translational vision science & technology · 2024Article
- Light-adapted flicker-optoretinography based on raster-scan optical coherence tomography towards clinical translation.Biomedical optics express · 2024Article
- Unique yellow shifts for small and brief stimuli in the central retina.Journal of vision · 2024Article
- Parafoveal cone function in choroideremia assessed with adaptive optics optoretinography.Scientific reports · 2024Article
- Intensity-based optoretinography reveals sub-clinical deficits in cone function in retinitis pigmentosa.Frontiers in ophthalmology · 2024Article
- Introduction to the Feature Issue on Adaptive Optics for Biomedical Applications.Biomedical optics express · 2023Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Light propagation in photoreceptor outer segments is affected by photopigment absorption and the phototransduction amplification cascade. Photopigment absorption has been studied using retinal densitometry, while recently, optoretinography (ORG) has provided an avenue to probe changes in outer segment optical path length due to phototransduction. With adaptive optics (AO), both densitometry and ORG have been used for cone spectral classification based on the differential bleaching signatures of the three cone types. Here, we characterize cone classification by ORG, implemented in an AO line-scan optical coherence tomography (OCT), and compare it against densitometry. The cone mosaics of five color normal subjects were classified using ORG showing high probability (∼0.99), low error (<0.22%), high test-retest reliability (∼97%), and short imaging durations (< 1 hour). Of these, the cone spectral assignments in two subjects were compared against AO-scanning laser opthalmoscope densitometry. High agreement (mean: 91%) was observed between the two modalities in these two subjects, with measurements conducted 6-7 years apart. Overall, ORG benefits from higher sensitivity and dynamic range to probe cone photopigments compared to densitometry, and thus provides greater fidelity for cone spectral classification.
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Registered trials
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