Evidence map›Paper›PMID 36589540›Full record

ArticleFrontiers in aging neuroscience2022

Potential roles of oxidative distress on neurodegeneration in Parkinson's disease with neuropsychiatric symptoms.

Dan-Ning Li, Teng-Hong Lian, Wei-Jiao Zhang, Ya-Nan Zhang, Peng Guo, Hui-Ying Guan, Jing-Hui Li, Ming-Yue He, Wen-Jing Zhang, Wei-Jia Zhang and 3 more

Abstract read
In one paragraph

Article in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Dan-Ning LiDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Teng-Hong LianCenter for Cognitive Neurology, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Wei-Jiao ZhangDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Ya-Nan ZhangDepartment of Blood Transfusion, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Peng GuoCenter for Cognitive Neurology, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Hui-Ying GuanDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Jing-Hui LiDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Ming-Yue HeDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Wen-Jing ZhangDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Wei-Jia ZhangDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Dong-Mei LuoDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Xiao-Min WangDepartment of Physiology, Capital Medical University, Beijing, China.
Wei ZhangCenter for Cognitive Neurology, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Neuropsychiatric symptoms (NPSs) belong to a category of non-motor symptoms of Parkinson's disease (PD), which seriously compromise the quality of life and prognosis of PD. This study focused on the correlations between NPSs, free radicals, neuroinflammatory factors, and neuropathological proteins in cerebrospinal fluid (CSF) in patients with PD, aiming to provide insights into the potential mechanisms and therapeutic target for PD with NPSs (PD-NPSs). Methods: In total, 129 patients with PD were enrolled and assessed by the Neuropsychiatric Symptoms Inventory (NPI); they were divided into the PD-NPSs group (75 patients) and PD with no NPSs (PD-nNPSs) group (54 patients). The levels of hydrogen peroxide (H Results: (1) The levels of H Conclusion: Oxidative distress characterized by the elevations of H

Indexed as

anti-oxidative enzymecerebrospinal fluidfree radicalsneuropathological proteinsneuropsychiatric symptomsParkinson's disease

Identifiers

PMID36589540
PMCPMC9797725

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.