ReviewFrontiers in aging neuroscience2022
An update on the use of gamma (multi)sensory stimulation for Alzheimer's disease treatment.
Review in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06322524 (Shanxi Key Laboratory of Artificial Intelligence Assisted Diagnosis and Treatment for Mental Disorder), which is not on this map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Shanxi Key Laboratory of Artificial Intelligence Assisted Diagnosis and Treatment for Mental Disorder
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Cognitive and Neuropathophysiological Outcomes of Gamma-tACS in Dementia: A Systematic Review.Neuropsychology review · 2024Pooled it
- A qualitative exploration of 40 Hz sound and music for older adults with mild cognitive impairment.Geriatric nursing (New York, N.Y.)Trial
- Before the task begins: linking resting-state gamma oscillations to face-name associative memory.Cognitive neurodynamics · 2026Article
- Gamma Oscillations, Sensory Stimulation, and Glymphatic Function: Toward User-Friendly Auditory Interventions for Brain Health in Aging and Neurodegeneration.Medical sciences (Basel, Switzerland) · 2026Review
- High intensity 40 Hz flicker improves amyloid pathology and cognition with autophagy in 3xTg mice.iScience · 2026Article
- Physical exercise in combination with audiovisual stimulation alleviates cognitive and affective impairments in Alzheimer's disease model mice via restoring lysosomal membrane integrity.Alzheimer's research & therapy · 2026Article
- Audiovisual gamma stimulation restores hippocampal neurogenesis and neural circuit plasticity in aging mice.Molecular psychiatry · 2026Article
- Cultural background and instrument timbre shape emotional and EEG responses to a familiar Middle Eastern melody in Maqam Saba: a crossover clinical trial with implications for music therapy.Frontiers in human neuroscience · 2026Article
- Non-invasive neuromodulation techniques for cognitive impairment intervention.American journal of translational research · 2026Review
- Light-based 40 Hz sensory therapy for brain disorders: physiological basis, therapeutic mechanisms, and future prospects.Frontiers in medicine · 2026Review
- Personalized audiovisual gamma stimulation enhances neural connectivity and entrainment beyond fixed 40 Hz protocols.Frontiers in neuroscience · 2026Article
- Regular cannabis use modulates gamma functional connectivity with V1 during visual processing.NeuroImage · 2025Article
- Review
- Audio-Visual Entrainment Neuromodulation: A Review of Technical and Functional Aspects.Brain sciences · 2025Review
- Investigating Gamma Frequency Band PSD in Alzheimer's Disease Using qEEG from Eyes-Open and Eyes-Closed Resting States.Journal of clinical medicine · 2025Article
- An Integrative Review of Brainwave Entrainment Benefits for Human Health.Applied psychophysiology and biofeedback · 2025Review
- Diagnosis of Cognitive and Mental Disorders: A New Approach Based on Spectral-Spatiotemporal Analysis and Local Graph Structures of Electroencephalogram Signals.Brain sciences · 2025Article
- Mystery of gamma wave stimulation in brain disorders.Molecular neurodegeneration · 2024Review
- Aging-associated sensory decline and Alzheimer's disease.Molecular neurodegeneration · 2024Review
- Sensory stimulation enhances visual working memory capacity.Communications psychology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alzheimer's disease (AD) is characterized by reduced fast brain oscillations in the gamma band (γ, > 30 Hz). Several animal studies show that inducing gamma oscillations through (multi)sensory stimulation at 40 Hz has the potential to impact AD-related cognitive decline and neuropathological processes, including amyloid plaques deposition, neurofibrillary tangles formation, and neuronal and synaptic loss. Therefore Gamma Entrainment Using Sensory stimulation (GENUS) is among the most promising approaches for AD patients' treatment. This review summarizes the evidence on GENUS effectiveness, from animal models to AD patients. Despite the application on human is in its infancy, the available findings suggest its feasibility for the treatment of AD. We discuss such results in light of parameter improvement and possible underlying mechanisms. We finally emphasize the need for further research for its development as a disease-modifying non-pharmacological intervention.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.