Evidence map›Paper›PMID 36589449›Full record

ArticleFrontiers in physiology2022

Exaggerated blood pressure response to static exercise in hindlimb ischemia-reperfusion.

Lu Qin, Jianhua Li

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Amplified P2XExperimental physiology · 2024
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Lu QinHeart and Vascular Institute, The Pennsylvania State University College of Medicine, Hershey, PA, United States.
Jianhua LiHeart and Vascular Institute, The Pennsylvania State University College of Medicine, Hershey, PA, United States.
Penn State Milton S. Hershey Medical Center · USPennsylvania State University · US

Funding

Project 3: Role Played by ASIC, P2X and EP4 Receptors in the Exercise Pressor Reflex in Health and Simulated PADP01HL134609 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KAUFMAN, MARC PETER · 2017 to 2021
$9.4M
Exercise Pressor Reflex in Peripheral Artery Disease: Roles of Flow Limitation and ReperfusionR01HL164571 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI JIAN CUI, JIANHUA LI · 2022 to 2026
$3.9M
Exercise pressor reflex in peripheral artery disease: beneficial effects of heating and mechanismsR01HL141198 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI CUI, JIAN, LI, JIANHUA · 2019 to 2023
$3.7M
NHLBI NIH HHS P01 HL134609NHLBI NIH HHS R01 HL141198NHLBI NIH HHS R01 HL164571
6 · The paper itself

Abstract

Peripheral artery disease (PAD) reduces the blood flow supply in the affected limbs as one of the significant cardiovascular concerns. Revascularization surgery in the femoral artery plays a central role in treating PAD. Exercise is also a rehabilitation strategy suggested for PAD patients to improve vascular functions. However, the effects of limb ischemia-reperfusion (IR), one of the most predominant complications in revascularization surgery, on exercise-induced arterial blood pressure (BP) response are poorly understood. In the present study, we determined 1) the blood flow status in the hindlimb muscles of rats (plantar muscle, red and white portions of gastrocnemius) with different time points of the hindlimb IR; and 2) the BP response to static muscle contraction in rats at different time points after the blood flow reperfusion procedure. Results of this study indicated that, compared with the Sham group, the blood flow in the hindlimb muscles evaluated by Evans blue concentration was significantly reduced at 6 h of femoral artery occlusion (FAO 6 h) (vs. sham control,

Indexed as

blood pressurehindlimb ischemia-reperfusionmuscle afferentperipheral artery diseasesympathetic nerve activity

Identifiers

PMID36589449
PMCPMC9794987
OpenAlexW4311357010

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.