Evidence map›Paper›PMID 36589019›Full record

ArticleBasic and clinical neuroscience

Protective Effect of the

Mahmood Abedinzade, Ekram Mohammadi, Mojtaba Hedayati, Iraj Nikokar, Korosh Khanaki, Zahra Bostani

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Basic and clinical neuroscience. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Mahmood AbedinzadeMedical Biotechnology Research Center, Department of Physiology, School of Paramedicine, Guilan University of Medical Sciences, Rasht, Iran.ORCID https://orcid.org/0000-0003-3436-7460
Ekram MohammadiDepartment of Medical Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.ORCID https://orcid.org/0000-0003-3436-7460
Mojtaba HedayatiDepartment of Microbiology, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran.ORCID https://orcid.org/0000-0002-2665-1050
Iraj NikokarMedical Biotechnology Research Center, Department of Laboratory of Microbiology, School of Nursing, Midwifery, and Paramedicine, Guilan University of Medical Sciences, Rasht, Iran.
Korosh KhanakiMedical Biotechnology Research Center, Department of Clinical Biochemistry, School of Paramedicine, Guilan University of Medical Sciences, Rasht, Iran.ORCID https://orcid.org/0000-0003-0733-6933
Zahra BostaniSocial Determinants of Health Research Center, School of Nursing and Midwifery, Guilan University of Medical Sciences, Rasht, Iran.ORCID https://orcid.org/0000-0001-5531-0506
Guilan University of Medical Sciences · IRIran University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Viola plant has been used traditionally to treat neurological disorders. We aimed at determining whether pretreatment with Methods: Male Wistar rats were divided into two main groups: one main group for evaluating Neurologic Deficit Score (NDS) and Infarct Volume (IV) and the other group for the evaluation of Results: In the V5 and V10 subgroups, NDS and IV significantly decreased. MCAO upregulated Conclusion: Highlights: MCAO results Infarct Volume (IV) and Neurologic Deficit Score (NDS);MCAO upregulated NCX3 gene expression in brain tissues;Viola spathulata extract pretreatment decreased IV and NDS in brain ischemia;Viola spathulata pretreatment downregulated NCX3 gene expression in brain tissues. Plain Language Summary: Stroke is the second leading cause of death and long term disability. Recently it has been reported that herbal extracts have protective role in ischemia injury. In Iranian traditional medicine Viola plant has a long history to treat disorders such as cancer. So we designed an animal study to investigate Viola plant extract in brain ischemia injury. Viola spathulata extract was administrated to rats for seven days, then animal model of brain ischemia was operated on them and some behavioral, histological and molecular factors were analyzed. Our findings showed that Viola spathulata extract improved behavioral disability, decreased infarct volume in brain tissue, and modulate Sodium/Calcium exchanger 3 gene expression. It could be concluded that Viola spathulata has the neuroprotective effect in animal stroke model and is a good candidate for nutritional supplements, although further studies are needed.

Indexed as

Brain ischemiaNCX3 geneNeuroprotectiveStrokeViola extractViola spathulata

Identifiers

PMID36589019
PMCPMC9790097
OpenAlexW3176422621

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.