Evidence map›Paper›PMID 36588884›Full record

ArticleFrontiers in neurology2022

Endovascular treatment of acute ischemic stroke with a fully radiopaque retriever: A randomized controlled trial.

Yongxin Zhang, Pei Liu, Zifu Li, Ya Peng, Wenhuo Chen, Liyong Zhang, Jianfeng Chu, Dong Kuai, Zhen Chen, Wei Wu and 22 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04995757 (Prospective, Randomized, Controlled, Open Label, Single Blinded, All China, Multi-Center, Registration Trial of the Thrombectomy System for the Treatment of Acute Ischemic Stroke.), which is not on this map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04995757 nacompletednot on this map

Prospective, Randomized, Controlled, Open Label, Single Blinded, All China, Multi-Center, Registration Trial of the Thrombectomy System for the Treatment of Acute Ischemic Stroke.

TypeinterventionalSponsorChanghai HospitalRan2018 to 2020Enrolled239ConditionsAcute Ischemic StrokeArmsStent Retriever
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors at 20 institutions in 1 country.

Yongxin ZhangNeurovascular Center, Changhai Hospital, Naval Military Medical University, Shanghai, China.
Pei LiuNeurovascular Center, Changhai Hospital, Naval Military Medical University, Shanghai, China.
Zifu LiNeurovascular Center, Changhai Hospital, Naval Military Medical University, Shanghai, China.
Ya PengDepartment of Neurosurgery, Changzhou First People's Hospital, Changzhou, China.
Wenhuo ChenDepartment of Neurology, Zhangzhou Hospital Affiliated to Fujian Medical University, Zhangzhou, China.
Liyong ZhangDepartment of Neurosurgery, Liaocheng People's Hospital Brain Hospital, Liaocheng, China.
Jianfeng ChuDepartment of Neurology, The First People's Hospital of Jining City, Jining, China.
Dong KuaiDepartment of Neurosurgery, Shanxi Provincial Cardiovascular Hospital, Taiyuan, China.
Zhen ChenDepartment of Neurointervention, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Wei WuDepartment of Neurology, Qilu Hospital of Shandong University, Jinan, China.
Yun XuDepartment of Neurology, Nanjing Gulou Hospital, Nanjing, China.
Yong ZhangDepartment of Neurology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Bin ZhouDepartment of Neurointervention, Cerebrovascular Disease Center, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China.
Yu GengDepartment of Neurology, Zhejiang Provincial People's Hospital, Hangzhou, China.
Congguo YinDepartment of Neurology, Hangzhou First People's Hospital, Hangzhou, China.
Jiang LiDepartment of Neurosurgery, The Second Affiliated Hospital of Air Force Military Medical University, Xi'an, China.
Ming WangDepartment of Neurointervention, Nanyang Second People's Hospital, Nanyang, China.
Naichi ZhaiDepartment of Neurosurgery, Zibo Central Hospital, Zibo, China.
Xiaoxiang PengDepartment of Neurology, The Third People's Hospital of Hubei Province, Wuhan, China.
Zhong JiDepartment of Neurology, Nanfang Hospital of Southern Medical University, Guangzhou, China.
Yaping XiaoDepartment of Neurology, Shanghai Oriental Hospital, Shanghai, China.
Xingen ZhuDepartment of Neurosurgery, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Xueli CaiDepartment of Neurology, Lishui Municipal Central Hospital, Lishui, China.
Lei ZhangNeurovascular Center, Changhai Hospital, Naval Military Medical University, Shanghai, China.
Bo HongNeurovascular Center, Shanghai General Hospital, Shanghai, China.
Pengfei XingNeurovascular Center, Changhai Hospital, Naval Military Medical University, Shanghai, China.
Hongjian ShenNeurovascular Center, Changhai Hospital, Naval Military Medical University, Shanghai, China.
Yongwei ZhangNeurovascular Center, Changhai Hospital, Naval Military Medical University, Shanghai, China.
Minghua LiInstitute of Diagnostic and Interventional Neuroradiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Meixia ShangDepartment of Biostatistics, Peking University First Hospital, Beijing, China.
Jianmin LiuNeurovascular Center, Changhai Hospital, Naval Military Medical University, Shanghai, China.
Pengfei YangNeurovascular Center, Changhai Hospital, Naval Military Medical University, Shanghai, China.
Changhai Hospital · CNSecond Military Medical University · CNAffiliated Hospital of Qingdao University · CNAir Force Medical University · CNCentral Hospital of Zibo · CNFirst Affiliated Hospital of Zhengzhou University · CNHangzhou First People's Hospital · CNHubei Zhongshan Hospital · CNJining First People's Hospital · CNLianyungang Oriental Hospital · CNLishui Central Hospital · CNNanchang University · CNPeking University First Hospital · CNQilu Hospital of Shandong University · CNShanghai First People's Hospital · CNShanghai Jiao Tong University · CNShanxi Cardiovascular Hospital · CNSouthern Medical University · CNSun Yat-sen University · CNThe First People's Hospital of Changzhou · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The Neurohawk retriever is a new fully radiopaque retriever. A randomized controlled non-inferiority trial was conducted to compare the Neurohawk and the Solitaire FR in terms of safety and efficacy. In order to evaluate the efficacy and safety of endovascular treatment in acute ischemic stroke (AIS) caused by intracranial atherosclerotic disease (ICAD) larger vessel occlusion (LVO), a sub-analysis was performed. Methods: Acute ischemic stroke patients aged 18-80 years with LVO in the anterior circulation were randomly assigned to undergo thrombectomy with either the Neurohawk or the Solitaire FR. The primary efficacy endpoint was successful reperfusion (mTICI 2b-3) rate by the allocated retriever. A relevant non-inferiority margin was 12.5%. Safety outcomes were symptomatic intracranial hemorrhage (sICH) and all-cause mortality within 90 days. Secondary endpoints included first-pass effect (FPE), modified FPE, and favorable outcomes at 90 days. In subgroup analysis, the patients were divided into the ICAD group and non-ICAD group according to etiology, and baseline characteristics, angiographic, and clinical outcomes were compared. Results: A total of 232 patients were involved in this analysis (115 patients in the Neurohawk group and 117 in the Solitaire group). The rates of successful reperfusion with the allocated retriever were 88.70% in the Neurohawk group and 90.60% in the Solitaire group (95%CI of the difference, -9.74% to 5.94%; Conclusion: The Neurohawk retriever is non-inferior to the Solitaire FR in the mechanical thrombectomy of large vessel occlusion-acute ischemic stroke (LVO-AIS). The sub-analysis suggested that endovascular treatment including thrombectomy with the retriever and essential rescue angioplasty is effective and safe in AIS patients with intracranial atherosclerotic disease-larger vessel occlusion (ICAD-LVO). Clinical trial registration: https://clinicaltrials.gov/ct2/show/NCT04995757, number: NCT04995757.

Indexed as

acute ischemic strokea randomized controlled trialendovascular treatmentintracranial atherosclerotic diseasenew fully radiopaque retriever

Identifiers

PMID36588884
PMCPMC9796564
OpenAlexW4311432963

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.