Evidence map›Paper›PMID 36588689›Full record

ArticleFrontiers in pharmacology2022

Ginsenoside Rd protects transgenic

Lihan Mi, Meiling Fan, Tianjia Liu, Donglu Wu, Yang Wang, Fuqiang Li, Yong Cai, Zhidong Qiu, Da Liu, Lingling Cao

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Journal of ginseng research · 2025
    Review
  4. Article
  5. Frontiers in aging neuroscience · 2024
    Article
  6. Active Compounds ofPharmaceuticals (Basel, Switzerland) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Lihan MiSchool of Pharmacy, Changchun University of Chinese Medicine, Changchun, China.
Meiling FanAffiliated Hospital of Changchun University of Chinese Medicine, Changchun, China.
Tianjia LiuScientific Research Department, The Third Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, China.
Donglu WuKey Laboratory of Effective Components of Traditional Chinese Medicine, Changchun, China.
Yang WangKey Laboratory of Effective Components of Traditional Chinese Medicine, Changchun, China.
Fuqiang LiSchool of Life Sciences, Jilin University, Changchun, China.
Yong CaiSchool of Life Sciences, Jilin University, Changchun, China.
Zhidong QiuSchool of Pharmacy, Changchun University of Chinese Medicine, Changchun, China.
Da LiuSchool of Pharmacy, Changchun University of Chinese Medicine, Changchun, China.
Lingling CaoKey Laboratory of Effective Components of Traditional Chinese Medicine, Changchun, China.
Changchun University of Chinese Medicine · CNJilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is a serious public health issue but few drugs are currently available for the disease, and these only target the symptoms. It is well established that oxidative stress plays a crucial role in AD, and there is compelling evidence linking oxidative stress to β-amyloid (Aβ). An exciting source of potential new AD therapeutic medication possibilities is medicinal plants. Ginsenoside Rd (GS-Rd) is one of the main bioactive substances in ginseng extracts. In our study, we used a network pharmacology analysis to identify overlapping GS-Rd (therapeutic) and AD (disease)-relevant protein targets, gene ontology (GO) and bio-process annotation, and the KEGG pathway analysis data predicted that GS-Rd impacts multiple targets and pathways, such as the MAPK signal pathway and the JAT-STAT3 signaling pathway. We then assessed the role of GS-Rd in

Indexed as

alzheimer’s diseaseC. elegansginsenoside rdoxidative resistantβ-amyloid

Identifiers

PMID36588689
PMCPMC9797510
OpenAlexW4312223423

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.