ArticleFrontiers in cardiovascular medicine2022
Association between frailty and short- and long-term mortality in patients with critical acute myocardial infarction: Results from MIMIC-IV.
Article in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 12 citations in OpenAlex.
- Research Topics and Trends in MIMIC-IV: A Large ICU Database Relevant for Critical Care Nursing.Nursing in critical care · 2026Review
- Frailty scale with the best prediction of mortality in individuals diagnosed with acute coronary syndrome: systematic review and meta-analysis.Journal of geriatric cardiology : JGC · 2026Article
- The effects of invasive treatment on patients with frailty and non-ST-segment elevation myocardial infarction.Scientific reports · 2025Article
- Revascularization in frail patients with acute coronary syndromes: a retrospective longitudinal study.European heart journal · 2025Article
- Association between different hemoglobin glycation index and prognosis in patients with a first diagnosis of acute myocardial infarction: a retrospective study based on the MIMIC-IV database.Frontiers in cardiovascular medicine · 2025Article
- The Association of Myocardial Infarction History and Geriatric Syndromes in the Elderly: Data from the Cross-Sectional Study EVKALIPT.Journal of clinical medicine · 2024Article
- Impact of Frailty and Delirium Among Older Adults Admitted With Acute Decompensated Heart Failure.JACC. Advances · 2024Article
- Association of frailty and sarcopenia with short-term mortality in older critically ill patients.The journal of nutrition, health & aging · 2024Article
- Comment on: Benefit of primary and secondary prophylactic implantable cardioverter defibrillator in elderly patients.Clinical cardiology · 2024Article
- The association between frailty and in-hospital mortality in critically ill patients with congestive heart failure: results from MIMIC-IV database.Frontiers in cardiovascular medicine · 2024Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
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Abstract
Background: Frailty has been recognized as an important prognostic indicator in patients with acute myocardial infarction (AMI). However, no study has focused on critical AMI patients. We aimed to determine the impact of frailty on short- and long-term mortality risk in critical AMI patients. Methods: Data from the Medical Information Mart for Intensive Care (MIMIC)-IV database was used. Frailty was assessed using the Hospital Frailty Risk Score (HFRS). Outcomes were in-hospital mortality and 1-year mortality. Logistic regression and Cox proportional-hazards models were used to investigate the association between frailty and outcomes. Results: Among 5,003 critical AMI patients, 2,176 were non-frail (43.5%), 2,355 were pre-frail (47.1%), and 472 were frail (9.4%). The in-hospital mortality rate was 13.8%, and the 1-year mortality rate was 29.5%. In our multivariable model, frailty was significantly associated with in-hospital mortality [odds ratio (OR) = 1.30, 95% confidence interval (CI): 1.20-1.41] and 1-year mortality [hazard ratio (HR) = 1.29, 95% CI: 1.24-1.35] as a continuous variable (per five-score increase). When assessed as categorical variables, pre-frailty and frailty were both associated with in-hospital mortality (OR = 2.80, 95% CI: 2.19-3.59 and OR = 2.69, 95% CI: 1.93-3.73, respectively) and 1-year mortality (HR = 2.32, 95% CI: 2.00-2.69 and HR = 2.81, 95% CI: 2.33-3.39, respectively) after adjustment for confounders. Subgroup analysis showed that frailty was only associated with in-hospital mortality in critically ill patients with non-ST-segment elevation myocardial infarction (STEMI) but not STEMI ( Conclusion: Frailty, as assessed by the HFRS, was associated with both in-hospital and 1-year mortality in critical AMI patients. Frailty improves the prediction of short- and long-term mortality in critical AMI patients and may have potential clinical applications.
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