ArticleFrontiers in cardiovascular medicine2022
Impact of diastolic pulmonary gradient and pulmonary artery pulse index on outcomes in heart transplant patients-Results from the Eurotransplant database.
Article in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 3 citations in OpenAlex.
- Recent perioperative challenges in anesthesia during expansion of heart transplantation.Journal of cardiothoracic surgery · 2026Review
- Haemodynamic phenotypes of pulmonary hypertension associated with left heart disease: a moving target.The European respiratory journal · 2024Article
- Pulmonary artery pulsatility index predicts mechanical circulatory support following heart transplantation.JHLT open · 2024Article
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Authors and funding
8 authors at 5 institutions in 3 countries.
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No grant is acknowledged in the PubMed record.
Abstract
Background: Predicting complications associated with pulmonary hypertension (PH) after cardiac transplantation is an important factor when considering cardiac transplantation. The transpulmonary gradient (TPG) is recommended to quantify PH in transplant candidates. Nonetheless, PH remains a common driver of mortality. The diastolic pressure gradient (DPG) and pulmonary vascular resistance (PVR) can differentiate post- from combined pre- and post-capillary PH and may improve estimation of PH-associated risks. We used a large European cohort of transplant candidates to assess whether the pulmonary pulsatility index (PAPi), improves prediction of graft failure and mortality compared to DPG and PVR. Methods: Out of all patients undergoing heart transplantation between 2009 and 2019 in Eurotransplant member states ( Results: In 1,407 heart transplant patients with PH (79% male, median age 54 years, IQR 39-69 years), the median PVR was 2.5 WU (IQR 1.6 WU) with a median mPAP (pulmonary arterial pressure) of 32 mmHg (IQR 9 mmHg). Patients with low (< 3 mmHg) DPG had a better 5 year survival than those with higher DPG (log rank Conclusion: PAPI and PVR are associated with graft failure in patients with PH undergoing cardiac transplantation. DPG is associated with survival in this cohort.
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