Evidence map›Paper›PMID 36588346›Full record

ArticleThe Journal of infectious diseases2023

Characterization of Virulence-Associated Traits in Mycoplasma penetrans Strains Acting as Likely Etiological Agents of Idiopathic Nongonococcal Urethritis.

Nathan R Schwab, Natalie E Young, Davidson U Nzenwata, Evelyn Toh, Joseph A Mikulin, Timothy J Wilson, David E Nelson, Mitchell F Balish

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Screening the receptors forFrontiers in cellular and infection microbiology · 2025
    Article
  3. Frontiers in microbiology · 2025
    Article
  4. Prevalence ofOpen forum infectious diseases · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Nathan R SchwabDepartment of Microbiology, Miami University, Oxford, Ohio, USA.
Natalie E YoungDepartment of Microbiology, Miami University, Oxford, Ohio, USA.
Davidson U NzenwataDepartment of Microbiology, Miami University, Oxford, Ohio, USA.
Evelyn TohDepartment of Microbiology and Immunology, School of Medicine, Indiana University, Indianapolis, Indiana, USA.
Joseph A MikulinDepartment of Microbiology, Miami University, Oxford, Ohio, USA.
Timothy J WilsonDepartment of Microbiology, Miami University, Oxford, Ohio, USA.
David E NelsonDepartment of Microbiology and Immunology, School of Medicine, Indiana University, Indianapolis, Indiana, USA.
Mitchell F BalishDepartment of Microbiology, Miami University, Oxford, Ohio, USA.ORCID 0000-0002-2606-5481
Miami University · USIndiana University – Purdue University Indianapolis · US

Funding

The role of the urethral microbiome in idiopathic urethritis in menR01AI116706 · NIAID · INDIANA UNIVERSITY INDIANAPOLIS · PI NELSON, DAVID EMMET · 2016 to 2020
$3.6M
NIAID NIH HHS R01 AI116706
6 · The paper itself

Abstract

Mycoplasma penetrans is an emerging pathogen with a reduced genome. This bacterium has only previously been cultured from individuals with chronic immunodeficiencies. Here we report the characteristics of 4 M. penetrans isolates from the urine of immunocompetent males with nongonococcal urethritis, in comparison with strain HF-2 from an immunocompromised patient. Several features exhibited distinct differences between these isolates and HF-2. Unlike HF-2, all 4 were resistant to azithromycin. They exhibited greater sialic acid-dependent binding to erythrocytes, gliding motility speed, and H2O2 production than HF-2. All new isolates produced thinner capsules than HF-2. Invasiveness varied, with some isolates being more invasive than HF-2 and some less invasive. Cytotoxicity to HeLa cells was similar to HF-2, and all strains could clear extracellular traps produced by innate immune cells. We conclude that subtle differences among M. penetrans strains may be critical for this organism to establish an infection in an otherwise healthy individual.

Indexed as

Mycoplasma InfectionsMycoplasma penetransUrethritisHeLa CellsHumansHydrogen PeroxideMaleVirulenceHydrogen Peroxideidiopathic urethritisMycoplasma penetransnongonococcal urethritis

Identifiers

PMID36588346
PMCPMC10319971
OpenAlexW4313424651

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.