ArticleIndian journal of ophthalmology2023
Determination of the repeatability of corneal densitometry as measured with a Scheimpflug camera device in refractive surgery candidates.
Article in Indian journal of ophthalmology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 4 citations in OpenAlex.
- One-year effects of orthokeratology lens wear on objective visual quality and corneal densitometry in adolescents with myopia.PloS one · 2026Article
- Commentary: Precision - The hallmark of refractive surgery.Indian journal of ophthalmology · 2023Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Corneal densitometry analysis provides an objective measurement of corneal transparency in patients undergoing photorefractive keratectomy (PRK). To date, no study that focuses on determining the reliability and smallest real difference (SRD), specifically in PRK candidates, has been published. Methods: The study was conducted at Clínica de Oftalmología Sandiego, Medellín, Colombia. This was a prospective and analytical study. Refractive surgery candidates underwent Pentacam measurements twice with five minutes of difference. Repeatability of measurements was evaluated for every area using Wilcoxon signed-rank test, Spearman's rank-order correlation, and the intraclass correlation coefficient, followed by a within-subjects factor (S Results: A total of 110 eyes were included. The mean total densitometry was 18.67 ± 1.56 grayscale units (GSU) and 18.65 ± 1.49 GSU for the first and second measurements, respectively. Wilcoxon was non-significant (P > 0.05) while the intraclass correlation coefficient demonstrated an excellent agreement. SRD ranged from 0.21 GSU (posterior × 6-10 mm) to 1.79 GSU (total × 10-12 mm). Anterior depths and 10-12 mm annulus had consistently more variability and greater (worse) SRD. The 10-12 mm annulus showed great dispersion on the Bland-Altman plots. Conclusion: Corneal densitometry has an excellent repeatability in refractive surgery candidates for areas below 10 mm. Any densitometry change ≥1.0 GSU in areas under 10 mm should be considered as well above measurement noise and corresponding to a real change in measured parameters. The 10-12 mm area does not seem to be reliable enough in refractive surgery candidates to warrant surveillance after corneal-based surgery.
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