ArticleLight, science & applications2023
Tetra-color superresolution microscopy based on excitation spectral demixing.
Article in Light, science & applications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The trial behind it
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Who cites it
9 citing papers in PubMed.
- High-Throughput Hyperspectral and Multiplexed Super-Resolution Fluorescence Imaging by SP-STORM.JACS Au · 2026Article
- Advanced Imaging for Live-Cell Spatiotemporal Monitoring: Technologies and Applications.Research (Washington, D.C.) · 2026Review
- Molecular-scale isotropic 3D super-resolution microscopy via interference localization.Nature methods · 2026Article
- COChemical science · 2025Article
- Organelle landscape analysis using a multiparametric particle-based method.PLoS biology · 2024Article
- Real-time data processing in colorimetry camera-based single-molecule localization microscopy via CPU-GPU-FPGA heterogeneous computation.Biomedical optics express · 2024Article
- Multiplexed Nanoscopy via Buffer Exchange.ACS nano · 2024Article
- Review
- RegiSTORM: channel registration for multi-color stochastic optical reconstruction microscopy.BMC bioinformatics · 2023Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Multicolor imaging allows protein colocalizations and organelle interactions to be studied in biological research, which is especially important for single-molecule localization microscopy (SMLM). Here, we propose a multicolor method called excitation-resolved stochastic optical reconstruction microscopy (ExR-STORM). The method, which is based on the excitation spectrum of fluorescent dyes, successfully separated four spectrally very close far-red organic fluorophores utilizing three excitation lasers with cross-talk of less than 3%. Dyes that are only 5 nm apart in the emission spectrum were resolved, resulting in negligible chromatic aberrations. This method was extended to three-dimensional (3D) imaging by combining the astigmatic method, providing a powerful tool for resolving 3D morphologies at the nanoscale.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.