ArticlePediatric pulmonology2023
Diffuse alveolar hemorrhage in children with interstitial lung disease: Determine etiologies!
Article in Pediatric pulmonology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Diffuse Alveolar Hemorrhage Complicating Influenza A Infection in an Immunocompetent Infant: A Case Report with Focused Pediatric Review.Journal of clinical medicine · 2026Article
- Respiratory infection induced episode of alveolar hemorrhage (RIIEAH) in the pediatric diffuse alveolar hemorrhage: a retrospective single-center study.BMC pediatrics · 2025Article
- Emphysema: an ignored radiologic sign of diffuse alveolar hemorrhage.BMC pediatrics · 2025Article
- Pediatric cardiac patients with pulmonary hemorrhage supported on ECMO: An ELSO registry study.The journal of extra-corporeal technology · 2025Observational
- Pulmonary hemorrhagic syndromes.Pediatric pulmonology · 2025Review
- The Clinical Approach to Interstitial Lung Disease in Childhood: A Narrative Review Article.Children (Basel, Switzerland) · 2024Review
- The Human Phenotype Ontology in 2024: phenotypes around the world.Nucleic acids research · 2024Article
- Diffuse alveolar haemorrhage in children: an international multicentre study.ERJ open research · 2023Article
- Clinical profiles and mortality risk factors in pediatric pulmonary hemorrhage: a singlecenter study in Saudi Arabia.Annals of Saudi medicineArticle
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Authors and funding
19 authors at 8 institutions in 5 countries.
Funding
Abstract
objectiveDiffuse alveolar hemorrhage (DAH) in children is a rare condition resulting from different underlying diseases. This study aimed at describing characteristics and diagnostic measures in children with ILD (children's interstitial lung disease, chILD) and DAH to improve the diagnostic approach by increasing clinician's awareness of diagnostic shortcomings. PATIENTS AND
methodsA retrospective data analysis of patients with ILD and DAH treated in our own or collaborating centers between 01/07/1997 and 31/12/2020 was performed. Data on clinical courses and diagnostic measures were systematically retrieved as case-vignettes and investigated. To assess suitability of diagnostic software-algorithms, the Human Phenotype Ontology (HPO) was revised and expanded to optimize conditions of its associated tool the "Phenomizer."
resultsFor 97 (74%) of 131 patients, etiology of pulmonary hemorrhage was clarified. For 34 patients (26%), no underlying condition was found (termed as idiopathic pulmonary hemorrhage, IPH). Based on laboratory findings or clinical phenotype/comorbidities, 20 of these patients were assigned to descriptive clusters: IPH associated with autoimmune features (9), eosinophilia (5), renal disease (3) or multiorgan involvement (3). For 14 patients, no further differentiation was possible.
conclusionComplete and sometimes repeated diagnostics are essential for establishing the correct diagnosis in children with DAH. We suggest assignment of patients with IPH to descriptive clusters, which may also guide further research. Digital tools such as the Phenomizer/HPO are promising, but need to be extended to increase diagnostic accuracy.
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