Evidence map›Paper›PMID 36587872›Full record

ArticleBioorganic & medicinal chemistry letters2023

Synthesis and pharmacological validation of a novel radioligand for the orphan GPR88 receptor.

Ann M Decker, Md Toufiqur Rahman, Chad M Kormos, David Hesk, Emmanuel Darcq, Brigitte L Kieffer, Chunyang Jin

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry letters, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Ann M DeckerCenter for Drug Discovery, Research Triangle Institute, Research Triangle Park, NC 27709, USA. Electronic address: adecker@rti.org.
Md Toufiqur RahmanCenter for Drug Discovery, Research Triangle Institute, Research Triangle Park, NC 27709, USA. Electronic address: mrahman@rti.org.
Chad M KormosCenter for Drug Discovery, Research Triangle Institute, Research Triangle Park, NC 27709, USA. Electronic address: ckormos@rti.org.
David HeskCenter for Drug Discovery, Research Triangle Institute, Research Triangle Park, NC 27709, USA. Electronic address: dhesk@rti.org.
Emmanuel DarcqINSERM U1114, University of Strasbourg, Strasbourg 67085, France. Electronic address: edarcq@unistra.fr.
Brigitte L KiefferINSERM U1114, University of Strasbourg, Strasbourg 67085, France. Electronic address: brigitte.kieffer@unistra.fr.
Chunyang JinCenter for Drug Discovery, Research Triangle Institute, Research Triangle Park, NC 27709, USA. Electronic address: cjin@rti.org.
RTI International · USUniversité de Strasbourg · FR

Funding

Nr4a1 and GPR88 as novel gene targets for alcoholism: mouse genetic approachesU01AA016658 · NIAAA · UNIVERSITE DE STRASBOURG · PI LAURA ADELA HARSAN · 2006 to 2026
$3.8M
GPR88 Agonist for Alcoholism TreatmentR01AA026820 · NIAAA · RESEARCH TRIANGLE INSTITUTE · PI JIN, CHUNYANG, KIEFFER, BRIGITTE L. · 2018 to 2022
$2.4M
Preparation and characterization of radioligands for the orphan receptor GPR88R03AA029013 · NIAAA · RESEARCH TRIANGLE INSTITUTE · PI HESK, DAVID, JIN, CHUNYANG · 2020 to 2020
$220k
NIAAA NIH HHS R01 AA026820NIAAA NIH HHS R03 AA029013NIAAA NIH HHS U01 AA016658
6 · The paper itself

Abstract

GPR88 is an orphan G protein-coupled receptor which has been implicated in a number of striatal-associated disorders. Herein we describe the synthesis and pharmacological characterization of the first GPR88 radioligand, [

Indexed as

Carrier ProteinsReceptors, G-Protein-CoupledAnimalsCricetinaeCricetulusRadioligand AssayCarrier ProteinsReceptors, G-Protein-Coupled[(3)H]RTI-33GPR88Radioligand binding

Identifiers

PMID36587872
PMCPMC9852087
OpenAlexW4313400105

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.