Evidence map›Paper›PMID 36587768›Full record

ArticleThe Journal of biological chemistry2023

Carnitine octanoyltransferase is important for the assimilation of exogenous acetyl-L-carnitine into acetyl-CoA in mammalian cells.

Jake Hsu, Nina Fatuzzo, Nielson Weng, Wojciech Michno, Wentao Dong, Maryline Kienle, Yuqin Dai, Anca Pasca, Monther Abu-Remaileh, Natalie Rasgon and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Metabolic origin and significance of 3-methylglutaryl CoA.Clinica chimica acta; international journal of clinical chemistry · 2025
    Review
  8. Article
  9. Review
  10. Liver-specific actions of GH and IGF1 that protect against MASLD.Nature reviews. Endocrinology · 2025 · on this map
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Cell lipid biology in infections: an overview.Frontiers in cellular and infection microbiology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Jake HsuDepartment of Chemical Engineering, Stanford University, Stanford, California, USA.
Nina FatuzzoDepartment of Chemistry, Stanford University, Stanford, California, USA.
Nielson WengDepartment of Chemistry, Stanford University, Stanford, California, USA.
Wojciech MichnoDivision of Neonatology, Department of Pediatrics, Stanford University, Stanford, California, USA.
Wentao DongDepartment of Chemical Engineering, Stanford University, Stanford, California, USA; Department of Genetics, Stanford University, Stanford, California, USA.
Maryline KienleDepartment of Chemistry, Stanford University, Stanford, California, USA.
Yuqin DaiSarafan ChEM-H, Stanford, California, USA.
Anca PascaDivision of Neonatology, Department of Pediatrics, Stanford University, Stanford, California, USA.
Monther Abu-RemailehDepartment of Chemical Engineering, Stanford University, Stanford, California, USA; Department of Genetics, Stanford University, Stanford, California, USA; Sarafan ChEM-H, Stanford, California, USA.
Natalie RasgonDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, USA.
Benedetta BigioDepartment of Psychiatry, Grossman School of Medicine, New York University, New York, New York, USA.
Carla NascaDepartment of Psychiatry, Grossman School of Medicine, New York University, New York, New York, USA; Department of Neuroscience and Physiology, New York University Neuroscience Institute, Grossman School of Medicine, New York University, New York, New York, USA; Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York, USA.
Chaitan KhoslaDepartment of Chemical Engineering, Stanford University, Stanford, California, USA; Department of Chemistry, Stanford University, Stanford, California, USA; Sarafan ChEM-H, Stanford, California, USA. Electronic address: khosla@stanford.edu.
Stanford University · USNew York University · US

Funding

Innovations and mechanisms in tumor subcellular metabolismDP2CA271386 · NCI · STANFORD UNIVERSITY · PI ABU-REMAILEH, MONTHER · 2021 to 2024
$2.4M
Molecular Pharmacology Training ProgramT32GM136631 · NIGMS · STANFORD UNIVERSITY · PI BOGYO, MATTHEW, CHEN, JAMES K · 2021 to 2025
$2.0M
NCI NIH HHS DP2 CA271386NIGMS NIH HHS T32 GM136631
6 · The paper itself

Abstract

In eukaryotes, carnitine is best known for its ability to shuttle esterified fatty acids across mitochondrial membranes for β-oxidation. It also returns to the cytoplasm, in the form of acetyl-L-carnitine (LAC), some of the resulting acetyl groups for posttranslational protein modification and lipid biosynthesis. While dietary LAC supplementation has been clinically investigated, its effects on cellular metabolism are not well understood. To explain how exogenous LAC influences mammalian cell metabolism, we synthesized isotope-labeled forms of LAC and its analogs. In cultures of glucose-limited U87MG glioma cells, exogenous LAC contributed more robustly to intracellular acetyl-CoA pools than did β-hydroxybutyrate, the predominant circulating ketone body in mammals. The fact that most LAC-derived acetyl-CoA is cytosolic is evident from strong labeling of fatty acids in U87MG cells by exogenous

Indexed as

AcetylcarnitineAcetyl Coenzyme ACarnitineCarnitine AcyltransferasesCarnitine O-AcetyltransferaseCell Line, TumorFatty AcidsGlucoseHumansOxidation-ReductionAcetylcarnitineAcetyl Coenzyme ACarnitineCarnitine AcyltransferasesCarnitine O-Acetyltransferasecarnitine octanoyltransferaseFatty AcidsGlucoseacetylcarnitineacetyl coenzyme A (acetyl-CoA)cell metabolismenergy metabolismenzyme turnovermetabolic regulationmitochondrial metabolismperoxisome

Identifiers

PMID36587768
PMCPMC9898754
OpenAlexW4313334013

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.