Evidence map›Paper›PMID 36586874›Full record

ArticleThe Journal of the Acoustical Society of America2022

Sources of variability in auditory brainstem response thresholds in a mouse model of noise-induced hearing loss.

Katrina M Schrode, Micheal L Dent, Amanda M Lauer

Open access · hybridAbstract read
In one paragraph

Article in The Journal of the Acoustical Society of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
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  4. Strengthening Medial Olivocochlear Feedback Reduces the Developmental Impact of Early Noise Exposure.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Katrina M SchrodeDepartment of Otolaryngology-Head and Neck Surgery and Center for Hearing and Balance, Johns Hopkins University School of Medicine, 515 Traylor Building, 720 Rutland Avenue, Baltimore, Maryland 21205, USA.ORCID 0000-0002-9963-9642
Micheal L DentDepartment of Psychology, B76 Park Hall, University at Buffalo-SUNY, Buffalo, New York 14260, USA.ORCID 0000-0001-7462-501X
Amanda M LauerDepartment of Otolaryngology-Head and Neck Surgery and Center for Hearing and Balance, Johns Hopkins University School of Medicine, 515 Traylor Building, 720 Rutland Avenue, Baltimore, Maryland 21205, USA.ORCID 0000-0003-4184-7374
Johns Hopkins University · US

Funding

Training Program in Hearing and BalanceT32DC000023 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI CULLEN, KATHLEEN E · 1989 to 2025
$8.7M
Supplement for temporal bone tissue scanning equipmentR01DC016641 · NIDCD · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI DENT, MICHEAL L, LAUER, AMANDA M. · 2018 to 2022
$2.2M
Perceptual and central auditory consequences of noise-induced hearing lossR03DC012352 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI LAUER, AMANDA M. · 2013 to 2015
$495k
NIDCD NIH HHS R01 DC016641NIDCD NIH HHS R03 DC012352NIDCD NIH HHS T32 DC000023
6 · The paper itself

Abstract

Numerous and non-acoustic experimental factors can potentially influence experimental outcomes in animal models when measuring the effects of noise exposures. Subject-related factors, including species, strain, age, sex, body weight, and post-exposure measurement timepoints, influence the observed hearing deficits. Experimenter effects, such as experience with experimental techniques and animal handling, may also factor into reported thresholds. In this study, the influence of subject sex, body mass, age at noise exposure, and timepoint of post-exposure recording are reported from a large sample of CBA/CaJ mice. Auditory brainstem response (ABR) thresholds differed between noise-exposed and unexposed mice, although the differences varied across tone frequencies. Thresholds across age at noise exposures and measurement delays after exposure also differed for some timepoints. Higher body mass correlated with higher ABR thresholds for unexposed male and female mice, but not for noise-exposed mice. Together, these factors may contribute to differences in phenotypic outcomes observed across studies or even within a single laboratory.

Indexed as

Hearing Loss, Noise-InducedAcoustic StimulationAnimalsAuditory ThresholdDisease Models, AnimalEvoked Potentials, Auditory, Brain StemFemaleMaleMiceMice, Inbred CBA

Identifiers

PMID36586874
PMCPMC9756347
OpenAlexW4311731190

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.