Evidence map›Paper›PMID 36586541›Full record

ArticleNeuroImage2023

Striatal dopamine supports reward expectation and learning: A simultaneous PET/fMRI study.

Finnegan J Calabro, David F Montez, Bart Larsen, Charles M Laymon, William Foran, Michael N Hallquist, Julie C Price, Beatriz Luna

Open access · goldAbstract read
In one paragraph

Article in NeuroImage, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Pooled it
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  5. Observational
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  15. The effects of intermittent theta burst stimulation (iTBS) on resting-state brain entropy (BEN).Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Neural basis of reward expectancy inducing proactive aggression.Cognitive, affective & behavioral neuroscience · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Finnegan J CalabroDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: fjc20@pitt.edu.
David F MontezDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Bart LarsenDepartment of Psychology, University of Pittsburgh, Pittsburgh, PA, USA.
Charles M LaymonDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA; Department of Radiology, University of Pittsburgh, Pittsburgh, PA, USA.
William ForanDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Michael N HallquistDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA; Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Julie C PriceDepartment of Radiology, University of Pittsburgh, Pittsburgh, PA, USA; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
Beatriz LunaDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA; Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA.
University of Pittsburgh · USHarvard University · USUniversity of North Carolina at Chapel Hill · US

Funding

University of Pittsburgh Clinical and Translational Science InstituteUL1TR001857 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2016 to 2025
$129.3M
Reward Processing in AdolescenceR01MH080243 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LUNA, BEATRIZ · 2008 to 2019
$5.5M
Adolescent striatal neurophysiological maturation underlying the transition to adult stabilization of behaviorR37MH080243 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BEATRIZ LUNA · 2022 to 2026
$3.4M
NCATS NIH HHS UL1 TR001857NIMH NIH HHS R01 MH080243NIMH NIH HHS R37 MH080243
6 · The paper itself

Abstract

Converging evidence from both human neuroimaging and animal studies has supported a model of mesolimbic processing underlying reward learning behaviors, based on the computation of reward prediction errors. However, competing evidence supports human dopamine signaling in the basal ganglia as also contributing to the generation of higher order learning heuristics. Here, we present data from a large (N = 81, 18-30yo), multi-modal neuroimaging study using simultaneously acquired task fMRI, affording temporal resolution of reward system function, and PET imaging with [

Indexed as

DopamineMotivationAnimalsCorpus StriatumHumansMagnetic Resonance ImagingPositron-Emission TomographyRewardDopamineDopaminePET/fMRIReinforcement learning

Identifiers

PMID36586541
PMCPMC9983071
OpenAlexW4313197782

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.