Evidence map›Paper›PMID 36586530›Full record

ArticleNeuroscience letters2023

Neuronal melatonin type 1 receptor overexpression promotes M2 microglia polarization in cerebral ischemia/reperfusion-induced injury.

Yalikun Suofu, Abhishek Jauhari, Emilia S Nirmala, William A Mullins, Xiaomin Wang, Fang Li, Diane L Carlisle, Robert M Friedlander

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience letters, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Targeting diabetes-induced brain damage by photobiomodulation: evidence of multiorgan protection.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026
    Article
  2. Article
  3. Review
  4. Neuroprotective effects ofFrontiers in pharmacology · 2024
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Yalikun SuofuNeuroapoptosis Laboratory, Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Abhishek JauhariNeuroapoptosis Laboratory, Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Emilia S NirmalaNeuroapoptosis Laboratory, Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
William A MullinsNeuroapoptosis Laboratory, Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Xiaomin WangNeuroapoptosis Laboratory, Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Fang LiNeuroapoptosis Laboratory, Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Diane L CarlisleNeuroapoptosis Laboratory, Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Robert M FriedlanderNeuroapoptosis Laboratory, Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Electronic address: friedlanderr@upmc.edu.
University of Pittsburgh · US

Funding

Melatonin biosynthesis in neuronal mitochondriaR01NS100743 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FRIEDLANDER, ROBERT M. · 2018 to 2022
$2.0M
Functional Role of Micro RNAs in Huntington's Disease PathogenesisR01NS077748 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FRIEDLANDER, ROBERT M. · 2012 to 2015
$1.6M
NINDS NIH HHS R01 NS077748NINDS NIH HHS R01 NS100743
6 · The paper itself

Abstract

Microglial activation is readily detected following cerebral ischemia/reperfusion-induced injury. Activated microglia polarize into either classic pro-inflammatory M1 or protective M2 microglia following ischemia/reperfusion-induced injury. Melatonin is protective immediately after ischemia/reperfusion-induced brain injury. However, the ability of melatonin to affect longer-term recovery from ischemic/reperfusion-induced injury as well as its ability to modulate microglia/macrophage polarization are unknown. The goal of this study is to understand the impact of melatonin on mice 14 days after injury, as well as to understand how melatonin affects microglial polarization of neuronal MT

Indexed as

Brain IschemiaMelatoninReperfusion InjuryAnimalsInfarction, Middle Cerebral ArteryMiceMicrogliaNeuronsReceptors, MelatoninReperfusionMelatoninReceptors, MelatoninAnimal modelsBrain infarctionBrain ischemiaMelatoninMelatonin type 1 receptorMicrogliaNeuroprotection

Identifiers

PMID36586530
PMCPMC9936831
OpenAlexW4313379793

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.