Evidence map›Paper›PMID 36586474›Full record

ArticleNeuropharmacology2023

Ca

Srdjan M Joksimovic, Seyed Mohammadreza Ghodsi, Jasper A Heinsbroek, James E Orfila, Nicolas Busquet, Vesna Tesic, Robert Valdez, Brier Fine-Raquet, Vesna Jevtovic-Todorovic, Yogendra H Raol and 2 more

Open access · greenAbstract read
In one paragraph

Article in Neuropharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Role of Thalamic CaInternational journal of molecular sciences · 2025
    Article
  4. Experimental biology and medicine (Maywood, N.J.) · 2025
    Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Srdjan M JoksimovicDepartment of Anesthesiology, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA; Division of Neurology and CHOP Research Institute, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Seyed Mohammadreza GhodsiDepartment of Anesthesiology, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.
Jasper A HeinsbroekDepartment of Anesthesiology, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA; Neuroscience Graduate Program, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.
James E OrfilaDepartment of Anesthesiology, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA; Department of Neurological Surgery, The Ohio State University College of Medicine, Columbus, OH, USA.
Nicolas BusquetDepartment of Neurology, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.
Vesna TesicDepartment of Anesthesiology, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.
Robert ValdezDepartment of Pediatrics, Division of Neurology, Translational Epilepsy Research Program, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.
Brier Fine-RaquetDepartment of Anesthesiology, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.
Vesna Jevtovic-TodorovicDepartment of Anesthesiology, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA; Department of Pharmacology, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.
Yogendra H RaolDepartment of Pediatrics, Division of Neurology, Translational Epilepsy Research Program, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Rockville, MD, USA.
Paco S HersonDepartment of Anesthesiology, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA; Department of Neurological Surgery, The Ohio State University College of Medicine, Columbus, OH, USA.
Slobodan M TodorovicDepartment of Anesthesiology, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA; Neuroscience Graduate Program, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA. Electronic address: slobodan.todorovic@cuanschutz.edu.
University of Colorado Anschutz Medical Campus · USNeurological Surgery · USChildren's Hospital of Philadelphia · USNational Institutes of Health · US

Funding

Voltage-gated calcium channels as target for anestheticsR35GM141802 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI Slobodan M. Todorovic · 2021 to 2026
$3.1M
Novel neurosteroid anesthetics and developmental synaptogenesisR01HD097990 · NICHD · UNIVERSITY OF COLORADO DENVER · PI JEVTOVIC-TODOROVIC, VESNA · 2019 to 2023
$2.9M
Novel neurosteroid anesthetics and perioperative analgesiaR01GM123746 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI JEVTOVIC-TODOROVIC, VESNA · 2017 to 2025
$2.2M
In vivo imaging of thalamocortical excitability during anesthesiaR01GM102525 · NIGMS · UNIVERSITY OF VIRGINIA · PI TODOROVIC, SLOBODAN M. · 2014 to 2020
$2.0M
Dissecting Ventral Pallidal Subcircuit Contributions to Drug Seeking in AddictionDP5OD026407 · OD · UNIVERSITY OF COLORADO DENVER · PI HEINSBROEK, JASPER · 2019 to 2023
$1.9M
FVMPE-RS Riser System for in vivo and in vitro imaging on anesthesia-induced developmental neurotoxicityR01GM118197 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI JEVTOVIC-TODOROVIC, VESNA · 2016 to 2019
$1.7M
The role of CaV3.1 T-type calcium channels in cognitive functions mediated by the subicular circuitryK01MH121567 · NIMH · UNIVERSITY OF COLORADO DENVER · PI JOKSIMOVIC, SRDAN · 2020 to 2023
$573k
NICHD NIH HHS R01 HD097990NIGMS NIH HHS R01 GM102525NIGMS NIH HHS R01 GM118197NIGMS NIH HHS R01 GM123746NIGMS NIH HHS R35 GM141802NIH HHS DP5 OD026407NIMH NIH HHS K01 MH121567
6 · The paper itself

Abstract

The dorsal subiculum (dSub) is one of the key structures responsible for the formation of hippocampal memory traces but the contribution of individual ionic currents to its cognitive function is not well studied. Although we recently reported that low-voltage-activated T-type calcium channels (T-channels) are crucial for the burst firing pattern regulation in the dSub pyramidal neurons, their potential role in learning and memory remains unclear. Here we used in vivo local field potential recordings and miniscope calcium imaging in freely behaving mice coupled with pharmacological and genetic tools to address this gap in knowledge. We show that the Ca

Indexed as

Calcium Channels, T-TypeAction PotentialsAnimalsCalciumHippocampusMiceNeuronal PlasticitySpatial MemoryCalciumCalcium Channels, T-TypeBurstingHippocampusLearningLow voltage-activated

Identifiers

PMID36586474
PMCPMC9898223
OpenAlexW4313379961

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.