Evidence map›Paper›PMID 36585833›Full record

ReviewProtein science : a publication of the Protein Society2023

"Not-so-popular" orthogonal pairs in genetic code expansion.

Joseph Andrews, Qinglei Gan, Chenguang Fan

Open access · bronzeAbstract readReview
In one paragraph

Review in Protein science : a publication of the Protein Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
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  3. [Expression of YARS1 in hepatocellular carcinoma and its prognostic effect].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2025
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  4. BeyondChemical reviews · 2025
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  15. "Not-so-popular" orthogonal pairs in genetic code expansion.Protein science : a publication of the Protein Society · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Joseph AndrewsDepartment of Chemistry and Biochemistry, University of Arkansas, Fayetteville, Arkansas, USA.
Qinglei GanDepartment of Chemistry and Biochemistry, University of Arkansas, Fayetteville, Arkansas, USA.
Chenguang FanDepartment of Chemistry and Biochemistry, University of Arkansas, Fayetteville, Arkansas, USA.ORCID 0000-0003-0662-1185
University of Arkansas at Fayetteville · US

Funding

Unraveling Gene-Environment Interactions Shaping Metabolism: A Multi-Omics Analysis in DrosophilaP20GM139768 · NIGMS · UNIVERSITY OF ARKANSAS AT FAYETTEVILLE · PI Joanna Fiddler · 2021 to 2026
$17.0M
The role of lysine acetylation of human threonyl-tRNA synthetaseR15GM140433 · NIGMS · UNIVERSITY OF ARKANSAS AT FAYETTEVILLE · PI FAN, CHENGUANG · 2021 to 2021
$450k
NIGMS NIH HHS P20 GM139768NIGMS NIH HHS R15 GM140433
6 · The paper itself

Abstract

During the past decade, genetic code expansion has been proved to be a powerful tool for protein studies and engineering. As the key part, a series of orthogonal pairs have been developed to site-specifically incorporate hundreds of noncanonical amino acids (ncAAs) into proteins by using bacteria, yeast, mammalian cells, animals, or plants as hosts. Among them, the pair of tyrosyl-tRNA synthetase/tRNA

Indexed as

Amino Acyl-tRNA SynthetasesRNA, TransferAmino AcidsGenetic CodeProtein EngineeringSaccharomyces cerevisiaeAmino AcidsAmino Acyl-tRNA SynthetasesRNA, Transferaminoacyl-tRNA synthetasesgenetic code expansionnoncanonical amino acidsorthogonal translation systemstRNA

Identifiers

PMID36585833
PMCPMC9850438
OpenAlexW4313401491

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.