ArticleBMC cancer2022
Mendelian randomization study of causal link from gut microbiota to colorectal cancer.
Article in BMC cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Body mass index (BMI) and risk of lung cancer: a systematic review and meta-analysis of studies using directly measured and genetically proxied measures of BMI.Cancer causes & control : CCC · 2026Pooled it
- Dual-tracer PET/CT with [European journal of nuclear medicine and molecular imaging · 2026Trial
- 35 blood and urine biomarkers and digestive system cancers: A two-sample Mendelian randomization study.Medicine · 2026Article
- Metabolic modeling and functional genomics reveal taxa and host gene interactions in colorectal cancer.bioRxiv : the preprint server for biology · 2026Article
- [Causal relationship between gut microbiota and T cell subsets in the development of colorectal cancer: a Mendelian randomization analysis].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025Article
- Mendelian analysis reveals novel pancreatic cancer-associated gut bacteria with tumor-suppressive effects.Cellular oncology (Dordrecht, Netherlands) · 2025Article
- A Novel High-Throughput Anaerobic Culture Method to Evaluate Food Health Effects via Gut Microbiota Modulation.Food science & nutrition · 2025Article
- Exploring the gut microbiota associated with peripheral nerve invasion in colorectal cancer patients and constructing predictive models.BMC microbiology · 2025Article
- Bacteriophages, Antibiotics and Probiotics: Exploring the Microbial Battlefield of Colorectal Cancer.International journal of molecular sciences · 2025Review
- Notch signaling in the tumor immune microenvironment of colorectal cancer: mechanisms and therapeutic opportunities.Journal of translational medicine · 2025Review
- Role of gut microbiome in pathogenesis and treatment of diseases: Multidisciplinary experts' opinion of the Asian Medical Experts Academy (AMEA).Gut microbes reports · 2025Review
- Inflammatory Bowel Disease Mediates the Causal Relationship Between Gut Microbiota and Colorectal Cancer: Identification of Therapeutic Targets and Predictive Modeling.Journal of Cancer · 2025Article
- The role and challenges of intratumoral microbiota in colorectal cancer immunotherapy.Frontiers in pharmacology · 2025Review
- Causal relationship between dyslipidemia and diabetic neuropathy: a mendelian randomization study.Metabolic brain disease · 2024Article
- Surgical and Oncological Outcomes of Level III-IV Versus Level I-II Inferior Vena Cava Thrombectomy: A Decennial Experience of a High-Volume European Referral Center.Annals of surgical oncology · 2024Article
- Alternations in the human skin, gut and vaginal microbiomes in perimenopausal or postmenopausal Vulvar lichen sclerosus.Scientific reports · 2024Article
- Microbiome-enabled genomic selection improves prediction accuracy for nitrogen-related traits in maize.G3 (Bethesda, Md.) · 2024Article
- Epidermal microorganisms contributed to the toxic mechanism of nZVI and TCEP in earthworms by robbing metal elements and nutrients.Eco-Environment & Health · 2024Article
- Causal effects and metabolites mediators between immune cell and risk of colorectal cancer: a Mendelian randomization study.Frontiers in immunology · 2024Article
- Mendelian randomization and bioinformatics unveil potential links between gut microbial genera and colorectal cancer.Frontiers in genetics · 2024Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Recent studies have shown the relevance of gut microbiota in the occurrence and development of colorectal cancer (CRC), but the causal relationship remains unclear in the human population. The present study aims to assess the causal relationship from the gut microbiota to CRC and to identify specific causal microbe taxa via genome-wide association study (GWAS) summary statistics based two-sample Mendelian randomization (MR) analyses. Microbiome GWAS (MGWAS) in the TwinsUK 1,126 twin pairs was used as discovery exposure sample, and MGWAS in 1,812 northern German participants was used as replication exposure sample. GWAS of CRC in 387,156 participants from the UK Biobank (UKB) was used as the outcome sample. Bacteria were grouped into taxa features at both family and genus levels. In the discovery sample, a total of 30 bacteria features including 15 families and 15 genera were analyzed. Five features, including 2 families (Verrucomicrobiaceae and Enterobacteriaceae) and 3 genera (Akkermansia, Blautia, and Ruminococcus), were nominally significant. In the replication sample, the genus Blautia (discovery beta=-0.01, P = 0.04) was successfully replicated (replication beta=-0.18, P = 0.01) with consistent effect direction. Our findings identified genus Blautia that was causally associated with CRC, thus offering novel insights into the microbiota-mediated CRC development mechanism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.