Evidence map›Paper›PMID 36585622›Full record

ArticleBMC neurology2022

Limits on using the clock drawing test as a measure to evaluate patients with neurological disorders.

Raheleh Heyrani, Atiye Sarabi-Jamab, Jordan Grafman, Nesa Asadi, Sarvenaz Soltani, Fatemeh Sadat Mirfazeli, Mostafa Almasi-Dooghaei, Seyed Vahid Shariat, Amin Jahanbakhshi, Tara Khoeini and 1 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in BMC neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07514520 (Decision-making, Ethical Consent, and Interactive Dialogue in Ongoing Neurocognitive Decline - DECISION), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07514520 active not recruitingnot on this mapstarted 2025, after this paper: background citation

Decision-making, Ethical Consent, and Interactive Dialogue in Ongoing Neurocognitive Decline - DECISION

TypeobservationalSponsorLudwig-Maximilians - University of MunichRan2025 to 2026Enrolled100ConditionsAlzheimer Disease, Neurodegenerative Diseases
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Raheleh HeyraniDepartment of Psychiatry, School of Medicine, Mental Health Research Center, Psychosocial Health Research Institute, Iran University of Medical Sciences, Tehran, Iran.
Atiye Sarabi-JamabSchool of Cognitive Sciences, Institute for Research in Fundamental Sciences (IPM), Tehran, Iran.
Jordan GrafmanShirly Ryan AbilityLab, Departments of Physical Medicine and Rehabilitation, Neurology, Cognitive Neurology, and Alzheimer's Center, Chicago, IL, USA.
Nesa AsadiDepartment of Psychiatry, School of Medicine, Mental Health Research Center, Psychosocial Health Research Institute, Iran University of Medical Sciences, Tehran, Iran.
Sarvenaz SoltaniDepartment of Psychiatry, School of Medicine, Mental Health Research Center, Psychosocial Health Research Institute, Iran University of Medical Sciences, Tehran, Iran.
Fatemeh Sadat MirfazeliDepartment of Psychiatry, School of Medicine, Mental Health Research Center, Psychosocial Health Research Institute, Iran University of Medical Sciences, Tehran, Iran. mirfazeli.f@iums.ac.ir.
Mostafa Almasi-DooghaeiDepartment of Neurology, Firoozgar Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Seyed Vahid ShariatDepartment of Psychiatry, School of Medicine, Mental Health Research Center, Psychosocial Health Research Institute, Iran University of Medical Sciences, Tehran, Iran.
Amin JahanbakhshiDepartment of Neurosurgery, Skull Base Research Center, Rasool Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
Tara KhoeiniDepartment of Neurology, Firoozgar Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Mohammad Taghi JoghataeiCellular and Molecular Research Center (CMRC), Iran University of Medical Sciences, Tehran, Iran.
Iran University of Medical Sciences · IRFiroozgar General Hospital · IRInstitute for Research in Fundamental Sciences · IRNorthwestern University · USRasool Akram Hospital · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe Clock Drawing Test (CDT) is used as a quick-to-conduct test for the diagnosis of dementia and a screening tool for cognitive impairments in neurological disorders. However, the association between the pattern of CDT impairments and the location of brain lesions has been controversial. We examined whether there is an association between the CDT scores and the location of brain lesions using the two available scoring systems.

methodOne hundred five patients with brain lesions identified by CT scanning were recruited for this study. The Montreal Cognitive Assessment (MoCA) battery including the CDT were administered to all partcipants. To score the CDT, we used a qualitative scoring system devised by Rouleau et al. (1992). For the quantitative scoring system, we adapted the algorithm method used by Mendes-Santos et al. (2015) based on an earlier study by Sunderland et al. (1989). For analyses, a machine learning algorithm was used.

resultsRemarkably, 30% of the patients were not detected by the CDT. Quantitative and qualitative errors were categorized into different clusters. The classification algorithm did not differentiate the patients with traumatic brain injury 'TBI' from non-TBI, or the laterality of the lesion. In addition, the classification accuracy for identifying patients with specific lobe lesions was low, except for the parietal lobe with an accuracy of 63%.

conclusionThe CDT is not an accurate tool for detecting focal brain lesions. While the CDT still is beneficial for use with patients suspected of having a neurodegenerative disorder, it should be cautiously used with patients with focal neurological disorders.

Indexed as

Alzheimer DiseaseNervous System DiseasesFunctional LateralityHumansNeuropsychological TestsDiagnosisLocation of brain lesionsScreening toolThe clock drawing test

Identifiers

PMID36585622
PMCPMC9805016
OpenAlexW4313365101

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.