Evidence map›Paper›PMID 36585597›Full record

SynthesisNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2023

Sexual dysfunction therapeutic approaches in patients with multiple sclerosis: a systematic review.

Vasileios Giannopapas, Dimitrios Kitsos, Anthi Tsogka, John S Tzartos, Georgios Paraskevas, Georgios Tsivgoulis, Konstantinos Voumvourakis, Sotirios Giannopoulos, Daphne Bakalidou

Open access · hybridAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Tibial nerve stimulation in the management of primary sexual dysfunction in patients with multiple sclerosis: a pilot randomized control trial.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Trial
  3. Comparison of different telerehabilitation protocols for urogenital symptoms in females with multiple sclerosis: a randomized controlled trial.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Vasileios GiannopapasLaboratory of Neuromuscular & Cardiovascular Study of Motion (LANECASM), University of West Attica, Athens, Greece.
Dimitrios KitsosSecond Dept of Neurology, Attikon University Hospital, National & Kapodistrian University of Athens, Rimini 1, 12462, Athens, Greece.
Anthi TsogkaSecond Dept of Neurology, Attikon University Hospital, National & Kapodistrian University of Athens, Rimini 1, 12462, Athens, Greece.
John S TzartosSecond Dept of Neurology, Attikon University Hospital, National & Kapodistrian University of Athens, Rimini 1, 12462, Athens, Greece.
Georgios ParaskevasSecond Dept of Neurology, Attikon University Hospital, National & Kapodistrian University of Athens, Rimini 1, 12462, Athens, Greece.
Georgios TsivgoulisSecond Dept of Neurology, Attikon University Hospital, National & Kapodistrian University of Athens, Rimini 1, 12462, Athens, Greece.
Konstantinos VoumvourakisSecond Dept of Neurology, Attikon University Hospital, National & Kapodistrian University of Athens, Rimini 1, 12462, Athens, Greece.
Sotirios GiannopoulosSecond Dept of Neurology, Attikon University Hospital, National & Kapodistrian University of Athens, Rimini 1, 12462, Athens, Greece. sgiannop@uoi.gr.ORCID http://orcid.org/0000-0001-7443-5179
Daphne BakalidouLaboratory of Neuromuscular & Cardiovascular Study of Motion (LANECASM), University of West Attica, Athens, Greece.
National and Kapodistrian University of Athens · GRUniversity of West Attica · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveMultiple sclerosis (MS) is the most common chronic inflammatory demyelinating disease of the central nervous system (CNS). The most common clinical manifestations of MS are spasticity, pain, vesico-urethral disorders, cognitive impairments, chronic fatigue and sexual dysfunction. This review aims to explore the possible therapeutic options for managing sexual dysfunction in people with MS (PwMS).

methodA thorough search of the PubMed Medline database was performed. Records were limited to clinical studies published between 01/01/2010 up to 01/01/2022. The results were screened by the authors in pairs.

resultsThe search identified 36 records. After screening, 9 records met the inclusion-exclusion criteria and were assessed. The pharmacological approaches investigated the effectiveness of sildenafil, tadalafil and onabotulinumtoxinA. Of the interventional studies the non-pharmacological investigated, the effectiveness of aquatic exercises, the application of pelvic floor exercises,the combination of pelvic floor exercises and mindfulness technique, the combination of pelvic floor exercises and electro muscular stimulation with electromyograph biofeedback, the application of yoga techniques and the efficacy of assistive devices like the clitoral vacuum suction device and the vibration device.

conclusionThe management of sexual dysfunction in PwMS needs to be further investigated. A team of healthcare professionals should be involved in the management of SD in order to address not only the primary (MS-related) SD symptoms but the secondary and tertiary as well. The main limitations that were identified in the existing literature were related to MS disease features, sample characteristics and evaluation tools and batteries.

Indexed as

Multiple SclerosisSexual Dysfunction, PhysiologicalExercise TherapyHumansPainSildenafil CitrateSildenafil CitrateErectile dysfunctionMultiple sclerosisSexual dysfunctionSexual function

Identifiers

PMID36585597
PMCPMC9925549
OpenAlexW4313340195

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.