Evidence map›Paper›PMID 36585523›Full record

ArticleUrolithiasis2022

Haplotype of CaSR gene is associated with risk of renal stone disease in West Indian population.

Yash P Patel, Sachchida Nand Pandey, Sandip B Patel, Aditya Parikh, Shailesh Soni, Nitiraj Shete, Ratika Srivastava, Manan A Raval, Arvind P Ganpule, Samir G Patel and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Urolithiasis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Yash P PatelDepartment of Clinical Pharmacy, Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology, Changa, Anand, Gujarat, 388421, India.
Sachchida Nand PandeyDepartment of Pathology, Muljibhai Patel Urological Hospital, Nadiad, Gujarat, 387001, India.
Sandip B PatelDepartment of Pharmacology, L.M. College of Pharmacy, Ahmedabad, Gujarat, 380009, India.
Aditya ParikhDepartment of Urology, Muljibhai Patel Urological Hospital, Nadiad, Gujarat, 387001, India.
Shailesh SoniDepartment of Pathology, Muljibhai Patel Urological Hospital, Nadiad, Gujarat, 387001, India.
Nitiraj SheteMuljibhai Patel Urological Hospital, Nadiad, Gujarat, 387001, India.
Ratika SrivastavaDepartment of Biotechnology, School of Life Sciences, Babasaheb Bhimrao Ambedkar University (A Central University), Lucknow, UP, India.
Manan A RavalDepartment of Pharmacognosy and Phytochemistry, Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology, Changa, Anand, Gujarat, 388421, India.
Arvind P GanpuleDepartment of Urology, Muljibhai Patel Urological Hospital, Nadiad, Gujarat, 387001, India.
Samir G PatelDepartment of Pharmaceutical Chemistry and Analysis, Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology, Changa, Anand, Gujarat, 388421, India. samirpatel.ph@charusat.ac.in.
Mahesh R DesaiDepartment of Urology, Muljibhai Patel Urological Hospital, Nadiad, Gujarat, 387001, India.
Muljibhai Patel Urological Hospital · INCharotar University of Science and Technology · INBabasaheb Bhimrao Ambedkar University · INB.J. Medical College · IN

Funding

Charotar University of Science and Technology CHARUSATSEEDRESEARCHGRANT/RPCP/SAPAknowledge consortium of Gujarat KCG/SHODH/2020-21/Muljibhai Patel Urological Society Department of Urology Research Support Grant
6 · The paper itself

Abstract

Calcium is the most abundant metabolite involved in the stone matrix. The CaSR gene controls calcium homeostasis, and genetic variation in the CaSR gene could lead to the development of renal stone disease. Therefore, the current study has been designed to assess the association of genetic variants of CaSR gene polymorphisms with renal stone disease. A single-centric prospective study has been carried out on a total of 300 participants (150 cases and 150 controls). Serum levels of calcium, creatinine, parathyroid hormone, and 24 h urine metabolites were measured. Two polymorphisms, rs1801725 and rs1042636, of the CaSR gene, have been genotyped for each participant. T test, binary logistic regression, and Chi-square analysis were used for statistical analysis. Renal stone patients had significantly higher levels of serum parathyroid hormone, creatinine, and 24-h urine metabolites in comparison to the controls. CaSR gene variants, rs1801725 (GG) and rs1042636 (AA), both have shown significant association with renal stone disease. In addition, individuals having specific genotypes along with metabolic abnormalities such as hypercalcemia and hyperparathyroidism are found to be at a higher significant risk of developing the renal stone disease. In the present study, the haplotype of the CaSR gene has shown an association with renal stone disease. Individuals with hyperparathyroidism and hypercalcemia and risk genotype have a higher susceptibility to developing renal stone disease.

Indexed as

HypercalcemiaKidney CalculiCalciumCreatinineHaplotypesHumansParathyroid HormoneProspective StudiesReceptors, Calcium-SensingCalciumCASR protein, humanCreatinineParathyroid HormoneReceptors, Calcium-SensingCaSR gene polymorphismsHaplotype analysisRenal stone diseaseWest Indian population

Identifiers

PMID36585523
OpenAlexW4313454289

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.