ArticleNature cancer2023
Multiomics in primary and metastatic breast tumors from the AURORA US network finds microenvironment and epigenetic drivers of metastasis.
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Article in Nature cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 114 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
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114citing papers in PubMed, 1 pooled it
9.9field-weighted citation impact, top 1% of its field
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The trial behind it
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Who cites it
114 citing papers in PubMed, 1 synthesis or guideline pooled it, 109 citations in OpenAlex.
- Prognostic value of intrinsic subtypes in hormone-receptor-positive metastatic breast cancer: systematic review and meta-analysis.ESMO open · 2023Pooled it
- Pembrolizumab and Paclitaxel in Patients with HR+/HER2- Breast Cancer with HER2-Enriched or Basal-like Subtypes.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026Trial
- Breast cancer immunogenicity as a spectrum: evolving concepts and therapeutic implications.The Journal of clinical investigation · 2026Review
- Review
- The immunology of human breast cancer.Nature reviews. Immunology · 2026Review
- Primary Tumor Epigenetic and Transcriptomic Alterations Associated with Nodal Burden and Metastatic Risk in ER+/HER2- Breast Cancer.International journal of molecular sciences · 2026Article
- Article
- Neuro-immune crosstalk in lung cancer brain metastasis: mechanisms, therapeutic targets, and translational opportunities.Medical oncology (Northwood, London, England) · 2026Review
- DNA methylation profiling enables subclassification of mucinous ovarian carcinoma and distinguishes it from extraovarian mucinous metastases.Cell reports. Medicine · 2026Article
- Integrative Transcriptional and Chromatin Analyses Reveal Enhancer-Mediated Regulatory Programs Driving Breast Cancer Metastasis.Molecular cancer research : MCR · 2026Article
- Article
- A Network Pharmacology Review of Plant-Derived Anticancer Compounds in Lung, Breast, Colorectal and Prostate Cancer.International journal of molecular sciences · 2026Review
- TMEM216 inhibits breast cancer lung metastasis by modulating IGF1R-IRS4 signaling pathway.Nature communications · 2026Article
- Understanding and Overcoming Antibody-Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Distinct immune landscapes characterize highly versus minimally invasive brain metastases.JCI insight · 2026Article
- RET signaling as a mediator of estrogen receptor positive breast cancer brain metastasis.Communications biology · 2026Article
- Article
- Integrative multi-omics profiling reveals distinct evolutionary and immunogenic features of brain oligometastasis in lung adenocarcinoma.Genome medicine · 2026Article
- Drug resistance to antibody-drug conjugates: mechanisms, challenges, and perspectives.Cancer biology & medicine · 2026Review
- Glucocorticoid-Induced Proteome and Phosphoproteome Changes in Breast Cancer Cell Lines.Journal of proteome research · 2026Article
54 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
58 authors at 20 institutions in 2 countries.
Susana Garcia-Recio *University of North Carolina, Chapel Hill, NC, USA.
Toshinori Hinoue *Van Andel Institute, Grand Rapids, MI, USA.
Gregory L Wheeler *Nationwide Children's Hospital, Columbus, OH, USA.ORCID 0000-0002-3291-6537
Benjamin J Kelly *Nationwide Children's Hospital, Columbus, OH, USA.
Ana C Garrido-Castro *Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-5989-6636
Tomas PascualUniversity of North Carolina, Chapel Hill, NC, USA.
Aguirre A De CubasVanderbilt University Medical Center, Nashville, TN, USA.
Youli XiaUniversity of North Carolina, Chapel Hill, NC, USA.
Brooke M FelsheimUniversity of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0001-8421-8290
Marni B McClureUniversity of North Carolina, Chapel Hill, NC, USA.
Andrei RajkovicNationwide Children's Hospital, Columbus, OH, USA.
Ezgi KaraesmenNationwide Children's Hospital, Columbus, OH, USA.
Markia A SmithUniversity of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0002-7114-3776
Cheng FanUniversity of North Carolina, Chapel Hill, NC, USA.
Paula I Gonzalez EricssonVanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0002-6292-6963
Melinda E SandersVanderbilt University Medical Center, Nashville, TN, USA.
Chad J CreightonBaylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-6090-703X
Jay BowenNationwide Children's Hospital, Columbus, OH, USA.ORCID 0000-0001-6861-9043
Kristen LeraasNationwide Children's Hospital, Columbus, OH, USA.
Robyn T BurnsTranslational Breast Cancer Research Consortium, Baltimore, USA.
Sara CoppensNationwide Children's Hospital, Columbus, OH, USA.
Amy WhelessUniversity of North Carolina, Chapel Hill, NC, USA.
Salma RezkUniversity of North Carolina, Chapel Hill, NC, USA.
Amy L GarrettUniversity of North Carolina, Chapel Hill, NC, USA.
Joel S ParkerUniversity of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0003-2080-6901
Kelly K FoyVan Andel Institute, Grand Rapids, MI, USA.
Hui ShenVan Andel Institute, Grand Rapids, MI, USA.
Ben H ParkVanderbilt University Medical Center, Nashville, TN, USA.
Ian KropDana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Carey AndersDuke University, Durham, NC, USA.ORCID 0000-0001-9165-4074
Julie Gastier-FosterNationwide Children's Hospital, Columbus, OH, USA.
Mothaffar F RimawiBaylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-4284-5656
Rita NandaUniversity of Chicago, Chicago, IL, USA.ORCID 0000-0001-5248-0876
Nancy U LinDana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Claudine IsaacsGeorgetown University, Washington, DC, USA.
P Kelly MarcomDuke University, Durham, NC, USA.
Anna Maria StornioloIndiana University School of Medicine, Indianapolis, IN, USA.
Fergus J CouchMayo Clinic, Rochester, MN, USA.
Uma ChandranUPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
Michael DavisUPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
Jonathan SilversteinUPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-9252-6039
Alexander RopelewskiPittsburgh Supercomputing Center, Carnegie Mellon University, Pittsburgh, PA, USA.ORCID 0000-0001-6874-4477
Minetta C LiuMayo Clinic, Rochester, MN, USA.ORCID 0000-0002-8206-5232
Susan G HilsenbeckBaylor College of Medicine, Houston, TX, USA.
Larry NortonMemorial Sloan Kettering Cancer Center, New York, NY, USA.
Andrea L RichardsonJohns Hopkins University, Baltimore, MD, USA.
W Fraser SymmansMD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0002-1526-184X
Antonio C WolffJohns Hopkins University, Baltimore, MD, USA.
Nancy E DavidsonFred Hutchinson Cancer Research Center, University of Washington, Seattle, WA, USA.
Lisa A CareyUniversity of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0003-2388-4649
Adrian V LeeUPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0001-9917-514X
Justin M BalkoVanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0002-4263-5974
Katherine A HoadleyUniversity of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0002-1216-477X
Peter W LairdVan Andel Institute, Grand Rapids, MI, USA.ORCID 0000-0001-9117-3641
Elaine R MardisNationwide Children's Hospital, Columbus, OH, USA.ORCID 0000-0002-5892-1553
Tari A KingDana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
AURORA US Network
Charles M PerouUniversity of North Carolina, Chapel Hill, NC, USA. cperou@med.unc.edu.ORCID 0000-0001-9827-2247
University of North Carolina at Chapel Hill · USNationwide Children's Hospital · USUPMC Hillman Cancer Center · USVan Andel Institute · USVanderbilt University Medical Center · USBaylor College of Medicine · USHarvard University · USDuke University · USJohns Hopkins University · USMayo Clinic in Arizona · USMedical University of South Carolina · USBreast Cancer Research Foundation · USBrigham and Women's Hospital · USGeorgetown University · USIndiana University School of MedicineMemorial Sloan Kettering Cancer Center · USPittsburgh Supercomputing Center · USThe University of Texas MD Anderson Cancer Center · USUniversity of Illinois Chicago · USUniversity of Washington · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MVirology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI David Darr · 1985 to 2026
$201.5MTumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STACIE B DUSETZINA · 1995 to 2026
$172.8MTranslational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Jennifer A. Woyach · 1985 to 2026
$132.3MTissue Procurement & PathologyP50CA058223 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CHARLES M PEROU · 1992 to 2026
$59.3MTISSUE CoreP50CA098131 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PARK, BEN HO, PIETENPOL, JENNIFER A · 2003 to 2024
$48.7MRe-Entry Supplement: Investigation of Oral Microbial Enzymes for the Detection and Treatment of Periodontal DiseaseUL1TR002489 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSE, JOHN BERNARD, SHAHEEN, NICHOLAS J · 2018 to 2022
$48.6MUNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3MPredoctoral Training Program in Bioinformatics and Computational BiologyT32GM135123 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Michael Isaiah Love, William Valdar · 2021 to 2026
$1.7MActivation of transposable elements as an endogenous source of neoepitopes and mediators of tumor immunogenicityK01CA245231 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DE CUBAS, AGUIRRE A · 2020 to 2024
$600kEPA EP-D-14-002NCATS NIH HHS UL1 TR002489NCI NIH HHS K01 CA245231NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA016058NCI NIH HHS P30 CA016086NCI NIH HHS P30 CA068485NCI NIH HHS P50 CA058223NCI NIH HHS P50 CA098131NIEHS NIH HHS P30 ES010126NIGMS NIH HHS T32 GM135123
Abstract
The AURORA US Metastasis Project was established with the goal to identify molecular features associated with metastasis. We assayed 55 females with metastatic breast cancer (51 primary cancers and 102 metastases) by RNA sequencing, tumor/germline DNA exome and low-pass whole-genome sequencing and global DNA methylation microarrays. Expression subtype changes were observed in ~30% of samples and were coincident with DNA clonality shifts, especially involving HER2. Downregulation of estrogen receptor (ER)-mediated cell-cell adhesion genes through DNA methylation mechanisms was observed in metastases. Microenvironment differences varied according to tumor subtype; the ER
Indexed as
Mammary Neoplasms, AnimalTriple Negative Breast NeoplasmsAnimalsBreastDNA MethylationEpigenesis, GeneticFemaleHumansMultiomicsTumor Microenvironment
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