Evidence map›Paper›PMID 36585363›Full record

ArticleBioEssays : news and reviews in molecular, cellular and developmental biology2023

A protein-lipid complex that detoxifies free fatty acids.

Shaojie Cui, Jin Ye

Open access · greenAbstract read
In one paragraph

Article in BioEssays : news and reviews in molecular, cellular and developmental biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Ferroptosis: The Demise of Cells Through Phospholipid Peroxidation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Shaojie CuiDepartment of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Jin YeDepartment of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.ORCID 0000-0002-3179-4777
The University of Texas Southwestern Medical Center · US

Funding

UT Southwestern NORCP30DK127984 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Jeff G McDonald · 2022 to 2026
$7.4M
Topological regulation of transmembrane proteins through Regulated Alternative TranslocationR35GM140851 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI YE, JIN · 2021 to 2025
$2.2M
NIDDK NIH HHS P30 DK127984NIGMS NIH HHS R35 GM140851
6 · The paper itself

Abstract

Fatty acids (FAs) are well known to serve as substrates for reactions that provide cells with membranes and energy. In contrast to these metabolic reactions, the physiological importance of FAs themselves known as free FAs (FFAs) in cells remains obscure. Since accumulation of FFAs in cells is toxic, cells must develop mechanisms to detoxify FFAs. One such mechanism is to sequester free polyunsaturated FAs (PUFAs) into a droplet-like structure assembled by Fas-Associated Factor 1 (FAF1), a cytosolic protein. This sequestration limits access of PUFAs to Fe

Indexed as

Fatty Acids, NonesterifiedFatty Acids, UnsaturatedCell DeathFatty AcidsSignal TransductionFatty AcidsFatty Acids, NonesterifiedFatty Acids, Unsaturatedferroptosisfree fatty acidslipid peroxidationphospholipase A2polyunsaturated fatty acidsβ-Catenin

Identifiers

PMID36585363
PMCPMC9974861
OpenAlexW4313339544

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.