ArticleJournal of advanced research2023
Pathogenesis-related protein 1 suppresses oomycete pathogen by targeting against AMPK kinase complex.
Article in Journal of advanced research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 44 citations in OpenAlex.
- Fine-tuning of the CRWN2-NTL9 module to repress PR1 expression by a viral effector during geminivirus infection.Fundamental research · 2026Article
- Genome-Wide Identification and Expression Analysis of Pathogenesis-Related Protein 1 in Sweet Potato and Its Two Relatives.Food science & nutrition · 2026Article
- A Core Effector MoPce1 Is Required for the Pathogenicity of Magnaporthe oryzae by Modulating Catalase-Mediated HMolecular plant pathology · 2026Article
- Functional evaluation of pathogenesis-related protein-1 (PR1) genes in mung bean (Vigna radiata) response to Pythium myriotylum.BMC genomics · 2025Article
- The CAPE1 peptide confers resistance against bacterial wilt in tomato.Journal of experimental botany · 2025Article
- Involvement of Pathogenesis-Related Proteins and Their Roles in Abiotic Stress Responses in Plants.Biomolecules · 2025Review
- CottonGenes · 2025Article
- Mechanisms of Chinese Hickory Resistance to Dry Rot Disease byPlants (Basel, Switzerland) · 2025Article
- Validation ofJournal of fungi (Basel, Switzerland) · 2025Article
- CAP superfamily proteins (VdPRYs) manipulate plant immunity and contribute to the virulence ofMycology · 2025Article
- Zucchini yellow mosaic virus-induced hypersensitive response is associated with pathogenesis-related 1 protein expression and confers resistance in watermelon.Plant cell reports · 2024Article
- The TOR signalling pathway in fungal phytopathogens: A target for plant disease control.Molecular plant pathology · 2024Review
- The wheat pathogenesis-related protein (TdPR1.2) enhanced tolerance to abiotic and biotic stresses in transgenic Arabidopsis plants.Protoplasma · 2024Article
- Infection ofJournal of fungi (Basel, Switzerland) · 2024Article
- Pathogenesis-Related 1 (PR1) Protein Family Genes Involved in Sugarcane Responses toInternational journal of molecular sciences · 2024Article
- Akkermansia muciniphila Improves Depressive-Like Symptoms by Modulating the Level of 5-HT Neurotransmitters in the Gut and Brain of Mice.Molecular neurobiology · 2024Article
- Abscisic-acid-responsiveFrontiers in plant science · 2024Article
- Characterization of soybean chitinase genes induced by rhizobacteria involved in the defense againstFrontiers in plant science · 2024Article
- The function of plant PR1 and other members of the CAP protein superfamily in plant-pathogen interactions.Molecular plant pathology · 2023Review
- Identification of the Function of the Pathogenesis-Related Protein GmPR1L in the Resistance of Soybean toGenes · 2023Article
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Authors and funding
13 authors at 9 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionDuring the arms race between plants and pathogens, pathogenesis-related proteins (PR) in host plants play a crucial role in disease resistance, especially PR1. PR1 constitute a secretory peptide family, and their role in plant defense has been widely demonstrated in both hosts and in vitro. However, the mechanisms by which they control host-pathogen interactions and the nature of their targets within the pathogen remain poorly understood.
objectivesThe present study was aimed to investigate the anti-oomycete activity of secretory PR1 proteins and elaborate their underlying mechanisms.
methodsThis study was conducted in the potato-Phytophthora infestans pathosystem. After being induced by the pathogen infection, the cross-kingdom translocation of secretory PR1 was demonstrated by histochemical assays and western blot, and their targets in P. infestans were identified by yeast-two-hybrid assays, bimolecular fluorescence complementation assays, and co-immunoprecipitation assay.
resultsThe results showed that the expression of secretory PR1-encoding genes was induced during pathogen infection, and the host could deliver PR1 into P. infestans to inhibit its vegetative growth and pathogenicity. The translocated secretory PR1 targeted the subunits of the AMPK kinase complex in P. infestans, thus affecting the AMPK-driven phosphorylation of downstream target proteins, preventing ROS homeostasis, and down-regulating the expression of RxLR effectors.
conclusionThe results provide novel insights into the molecular function of PR1 in protecting plants against pathogen infection, and uncover a potential target for preventing pre- and post-harvest late blight.
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