Evidence map›Paper›PMID 36584971›Full record

ArticleJournal of the American Medical Directors Association2023

The Relationship of Oral Health with Progression of Physical Frailty among Older Adults: A Longitudinal Study Composed of Two Cohorts of Older Adults from the United Kingdom and United States.

Rachel Kimble, A Olia Papacosta, Lucy T Lennon, Peter H Whincup, Robert J Weyant, John C Mathers, S Goya Wannamethee, Sheena E Ramsay

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Medical Directors Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 3 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 37 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Rachel KimblePopulation Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK; Division of Sport and Exercise Science, School of Health and Life Sciences, University of the West of Scotland, Blantyre, UK. Electronic address: rachel.kimble@newcastle.ac.uk.
A Olia PapacostaDepartment of Primary Care and Population Health, UCL, London, UK.
Lucy T LennonDepartment of Primary Care and Population Health, UCL, London, UK.
Peter H WhincupPopulation Health Research Institute, St George's, University of London, London, UK.
Robert J WeyantDepartment of Dental Public Health, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
John C MathersPopulation Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK.
S Goya WannametheeDepartment of Primary Care and Population Health, UCL, London, UK.
Sheena E RamsayPopulation Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Newcastle University · GBUniversity College London · GBSt George's, University of London · GBUniversity of Pittsburgh · US

Funding

Peripheral Nerve Function Decline in an Aged CohortR01AG028050 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STROTMEYER, ELSA S. · 2007 to 2015
$3.5M
End of Life in the Very OldR01NR012459 · NINR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ALBERT, STEVEN M, LUNNEY, JUNE R · 2011 to 2015
$2.7M
Understanding the contribution of poor oral health to sarcopenia in older age and underlying mechanisms using UK and US cohort studiesR03DE028505 · NIDCR · UNIVERSITY OF NEWCASTLE · PI RAMSAY, SHEENA ESTHER · 2019 to 2020
$213k
British Heart Foundation PG/13/41/30304British Heart Foundation PG/13/86/30546British Heart Foundation RG/13/16/30528British Heart Foundation RG/19/4/34452Medical Research Council G1002391Medical Research Council MR/K006312/1Medical Research Council MR/K02325X/1Medical Research Council MR/L016354/1Medical Research Council MR/P020941/1NIA NIH HHS R01 AG028050NIDCR NIH HHS R03 DE028505NINR NIH HHS R01 NR012459The Dunhill Medical Trust R396/1114The Dunhill Medical Trust R592/0717
6 · The paper itself

Abstract

objectiveTo investigate the prospective associations between oral health and progression of physical frailty in older adults.

designProspective analysis. SETTING AND

participantsData are from the British Regional Heart Study (BRHS) comprising 2137 men aged 71 to 92 years from 24 British towns and the Health, Aging, and Body Composition (HABC) Study of 3075 men and women aged 70 to 79 years.

methodsOral health markers included denture use, tooth count, periodontal disease, self-rated oral health, dry mouth, and perceived difficulty eating. Physical frailty progression after ∼8 years follow-up was determined based on 2 scoring tools: the Fried frailty phenotype (for physical frailty) and the Gill index (for severe frailty). Logistic regression models were conducted to examine the associations between oral health markers and progression to frailty and severe frailty, adjusted for sociodemographic, behavioral, and health-related factors.

resultsAfter full adjustment, progression to frailty was associated with dentition [per each additional tooth, odds ratio (OR) 0.97; 95% CI: 0.95-1.00], <21 teeth with (OR 1.74; 95% CI: 1.02-2.96) or without denture use (OR 2.45; 95% CI 1.15-5.21), and symptoms of dry mouth (OR ≥1.8; 95% CI ≥ 1.06-3.10) in the BRHS cohort. In the HABC Study, progression to frailty was associated with dry mouth (OR 2.62; 95% CI 1.05-6.55), self-reported difficulty eating (OR 2.12; 95% CI 1.28-3.50) and ≥2 cumulative oral health problems (OR 2.29; 95% CI 1.17-4.50). Progression to severe frailty was associated with edentulism (OR 4.44; 95% CI 1.39-14.15) and <21 teeth without dentures after full adjustment. CONCLUSIONS AND IMPLICATIONS: These findings indicate that oral health problems, particularly tooth loss and dry mouth, in older adults are associated with progression to frailty in later life. Additional research is needed to determine if interventions aimed at maintaining (or improving) oral health can contribute to reducing the risk, and worsening, of physical frailty in older adults.

Indexed as

FrailtyTooth LossXerostomiaFemaleHumansLongitudinal StudiesOral HealthUnited Statesagingdry mouthfrailtyOral health problemstooth loss

Identifiers

PMID36584971
PMCPMC10398566
OpenAlexW4313339857

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.