Evidence map›Paper›PMID 36584932›Full record

ArticleFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association2023

Acute exposure to low-dose bisphenol A delays cardiac repolarization in female canine heart - Implication for proarrhythmic toxicity in large animals.

Jianyong Ma, Paul J Niklewski, Hong-Sheng Wang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Cardiotoxic effects of Bisphenol-A in male Wistar rats are attenuated byJournal of traditional and complementary medicine · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Choice of experimental model determines translational impact: The link between bisphenol A and cardiotoxicity.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jianyong MaDepartment of Pharmacology and Systems Physiology, University of Cincinnati, College of Medicine, Cincinnati, OH, USA.
Paul J NiklewskiDepartment of Pharmacology and Systems Physiology, University of Cincinnati, College of Medicine, Cincinnati, OH, USA.
Hong-Sheng WangDepartment of Pharmacology and Systems Physiology, University of Cincinnati, College of Medicine, Cincinnati, OH, USA. Electronic address: wanghs@uc.edu.
University of Cincinnati Medical Center · US

Funding

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY RESEARCHP30ES006096 · NIEHS · UNIVERSITY OF CINCINNATI · PI PINNEY, SUSAN MENGEL · 1992 to 2022
$35.4M
Endocrine Disruptors and Heart HealthR01ES027855 · NIEHS · UNIVERSITY OF CINCINNATI · PI RUBINSTEIN, JACK, WANG, HONG-SHENG · 2018 to 2022
$2.1M
Effects of environmental estrogen exposure on the heartR01ES017263 · NIEHS · UNIVERSITY OF CINCINNATI · PI WANG, HONG-SHENG · 2009 to 2013
$1.7M
NIEHS NIH HHS P30 ES006096NIEHS NIH HHS R01 ES017263NIEHS NIH HHS R01 ES027855
6 · The paper itself

Abstract

Bisphenol A (BPA) is a common environmental chemical with a range of potential adverse health effects. The impact of environmentally-relevant low dose of BPA on the electrical properties of the hearts of large animals (e.g., dog, human) is poorly defined. Perturbation of cardiac electrical properties is a key arrhythmogenic mechanism. In particular, delay of ventricular repolarization and prolongation of the QT interval of the electrocardiogram is a marker for the risk of malignant arrhythmias. We examined the acute effect of 10

Indexed as

Arrhythmias, CardiacPhenolsAnimalsBenzhydryl CompoundsBisphenol A CompoundsDogsFemaleMyocytes, CardiacBenzhydryl Compoundsbisphenol ABisphenol A CompoundsPhenolsArrhythmia markerBisphenol ACanine hearthERG channelLow doseQT prolongation

Identifiers

PMID36584932
PMCPMC9852101
OpenAlexW4312209772

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.