ArticleJournal of affective disorders2023
Positive relations mediate the bidirectional connections between depression and anxiety symptoms.
Article in Journal of affective disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Concurrent depression and anxiety in women undergoing additional diagnostic procedures due to positive screening for cervical cancer.PloS one · 2026Observational
- Argon improves microglia-mediated hippocampal neuronal hyperexcitability to alleviate anxiety-like behaviors in mice.Journal of molecular cell biology · 2025Article
- Psychological safety and trust as drivers of teachers' continued use of AI tools in classrooms.Scientific reports · 2025Article
- Mental health care cascade performance and associated factors: longitudinal analyses of routine Ministry of Health services in Mozambique.BMJ public health · 2025Article
- An Alternative Approach to Future Diagnosis: Can Generalized Anxiety Disorder Be Distinguished From Major Depressive Disorder, Healthy People by Differentially Expressed lncRNAs in Peripheral Blood.Neuropsychiatric disease and treatment · 2025Article
- Positive reappraisal coping mediates the relationship between parental abuse and lack of affection on adulthood generalized anxiety severity.Journal of anxiety disorders · 2024Article
- Commentary: Mastery is central: an examination of complex interrelationships between physical health, stress and adaptive cognition, and social connection with depression and anxiety symptoms.Frontiers in psychiatry · 2024Article
- The mediating effect of stress reactivity in the 18-year bidirectional relationship between generalized anxiety and depression severity.Journal of affective disorders · 2023Article
- The mediation effect analysis of nurse's mental health status and burnout under COVID-19 epidemic.Frontiers in public health · 2023Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
introductionMajor depressive disorder (MDD) and generalized anxiety disorder (GAD) co-occur at high rates, often preceding and predicting one another over long durations. Interpersonal theories propose that relationships with others may contribute to the longitudinal connections between MDD and GAD. Therefore, the current study examined the mediational effect of positive relations with others in these connections over 18 years.
methodsCommunity-dwelling adults (n = 3294) participated in data collection at three time-points (Time 1 [T1], Time 2 [T2], and Time 3 [T3]) spaced about nine years apart. MDD and GAD symptoms were assessed using the Composite International Diagnostic Interview-Short Form. Positive relations was measured with the Psychological Well-Being Scale-Positive Relations with Others subscale. Structural equation mediation modeling was used for data analysis.
resultsResults indicated that lower T2 positive relations significantly mediated the relationship between higher T1 MDD severity predicting more severe T3 GAD symptoms (d = 0.375) and explained 10.7% of the variance. T2 positive relations also had a significant mediational effect in the association between T1 GAD symptoms positively predicting T3 MDD severity (d = 0.360), accounting for 12.2% of the variance of this connection. These mediational effects were significant after adjusting for age, gender, education, and T1 symptoms (d = 0.277-0.677).
conclusionsSupporting interpersonal theories, lack of positive relations with others mediated the bidirectional connections between MDD and GAD symptoms across 18 years. Future research should continue to explore the influence of positive relations on mental health and whether treatments that enhance interpersonal functioning could improve treatment for depression and anxiety.
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