Evidence map›Paper›PMID 36584683›Full record

ArticleCell reports. Medicine2023

The Fc-effector function of COVID-19 convalescent plasma contributes to SARS-CoV-2 treatment efficacy in mice.

Irfan Ullah, Guillaume Beaudoin-Bussières, Kelly Symmes, Marc Cloutier, Eric Ducas, Alexandra Tauzin, Annemarie Laumaea, Michael W Grunst, Katrina Dionne, Jonathan Richard and 6 more

Open access · goldAbstract read
In one paragraph

Article in Cell reports. Medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 39 citations in OpenAlex.

  1. Trial
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  6. Emerging microbes & infections · 2025
    Article
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  8. Observational
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  12. BNT162b2 COVID-19 vaccination elicits the expansion of CD16The Journal of allergy and clinical immunology · 2025
    Article
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  15. Article
  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 2 countries.

Irfan UllahDepartment of Internal Medicine, Section of Infectious Diseases, Yale University School of Medicine, New Haven, CT 06520, USA.
Guillaume Beaudoin-BussièresCentre de Recherche du CHUM, Montréal, QC H2X0A9, Canada; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, QC H2X0A9, Canada.
Kelly SymmesDepartment of Internal Medicine, Section of Infectious Diseases, Yale University School of Medicine, New Haven, CT 06520, USA.
Marc CloutierHema-Quebec, Affaires Médicales et Innovation, Québec, QC G1V 5C3, Canada.
Eric DucasHema-Quebec, Affaires Médicales et Innovation, Québec, QC G1V 5C3, Canada.
Alexandra TauzinCentre de Recherche du CHUM, Montréal, QC H2X0A9, Canada; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, QC H2X0A9, Canada.
Annemarie LaumaeaCentre de Recherche du CHUM, Montréal, QC H2X0A9, Canada; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, QC H2X0A9, Canada.
Michael W GrunstDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06510, USA.
Katrina DionneCentre de Recherche du CHUM, Montréal, QC H2X0A9, Canada; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, QC H2X0A9, Canada.
Jonathan RichardCentre de Recherche du CHUM, Montréal, QC H2X0A9, Canada; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, QC H2X0A9, Canada.
Philippe BéginSection of Allergy, Immunology and Rheumatology, Department of Pediatrics, CHU Sainte-Justine, Montréal, QC, Canada; Department of Médicine, Centre Hospitalier de l'Université de Montréal, Montréal, QC, Canada.
Walther MothesDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06510, USA.
Priti KumarDepartment of Internal Medicine, Section of Infectious Diseases, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address: priti.kumar@yale.edu.
Renée BazinHema-Quebec, Affaires Médicales et Innovation, Québec, QC G1V 5C3, Canada. Electronic address: renee.bazin@hema-quebec.qc.ca.
Andrés FinziCentre de Recherche du CHUM, Montréal, QC H2X0A9, Canada; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, QC H2X0A9, Canada. Electronic address: andres.finzi@umontreal.ca.
Pradeep D UchilDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06510, USA. Electronic address: pradeep.uchil@yale.edu.
Yale University · USCentre Hospitalier de l’Université de Montréal · CAHéma-Québec · CAUniversité de Montréal · CACentre Hospitalier Universitaire Sainte-Justine · CA

Funding

Structure and Dynamics of the SARS-CoV-2 Spike ProteinR01AI163395 · NIAID · YALE UNIVERSITY · PI MOTHES, WALTHER H · 2021 to 2025
$4.1M
Predoctoral Training Program in VirologyT32AI055403 · NIAID · YALE UNIVERSITY · PI KUMAR, PRITI, MOTHES, WALTHER H · 2003 to 2024
$3.6M
NIAID NIH HHS R01 AI163395NIAID NIH HHS T32 AI055403
6 · The paper itself

Abstract

COVID-19 convalescent plasmas (CCPs) are chosen for plasma therapy based on neutralizing titers and anti-Spike immunoglobulin levels. However, CCP characteristics that promote SARS-CoV-2 control are complex and incompletely defined. Using an in vivo imaging approach, we demonstrate that CCPs with low neutralizing (ID

Indexed as

COVID-19SARS-CoV-2AnimalsCOVID-19 SerotherapyImmunoglobulin GMiceTreatment OutcomeImmunoglobulin GADCCconvalescent plasmaCOVID-19Fc-effectorIgAIgGIgMmacrophagesneutrophilsSARS-CoV-2

Identifiers

PMID36584683
PMCPMC9799175
OpenAlexW4313333208

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.