ArticleNeuron2023
Brainstem serotonin neurons selectively gate retinal information flow to thalamus.
Article in Neuron, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
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- Receptor architecture of the macaque lateral geniculate nucleus.Brain structure & function · 2026Article
- The 5-HT1A receptor antagonist WAY-100635 maleate promotes retinal ganglion cell differentiation and protects the retino-visual circuits.Communications medicine · 2026Article
- Astrocyte-induced internal state transitions reshape brainwide sensory, integrative, and motor computations.bioRxiv : the preprint server for biology · 2026Article
- The central histaminergic system slows visual processing in the retina and lateral geniculate nucleus of awake mice.PLoS biology · 2025Article
- Coordination of distinct sources of excitatory inputs enhances motion selectivity in the mouse visual thalamus.Neuron · 2025Article
- Limited transmission of mixed convergent signals at the mouse retinogeniculate synapse.Neuron · 2025Article
- Transcriptomics of Various Diseases Reveals the Core Role of Immune System Pathways in Retinal Damage Repair and Nerve Regeneration.Molecular neurobiology · 2025Article
- Serotonin regulates in a cell-type specific manner light-evoked response and synaptic activity in mouse retinal ganglion cells.Biological research · 2025Article
- Visual activity enhances neuronal excitability in thalamic relay neurons.Science advances · 2025Article
- Article
- Long-term optical imaging of the spinal cord in awake behaving mice.Nature methods · 2024Article
- Spiking activity in the visual thalamus is coupled to pupil dynamics across temporal scales.PLoS biology · 2024Article
- Activity-induced MeCP2 phosphorylation regulates retinogeniculate synapse refinement.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
Retinal ganglion cell (RGC) types relay parallel streams of visual feature information. We hypothesized that neuromodulators might efficiently control which visual information streams reach the cortex by selectively gating transmission from specific RGC axons in the thalamus. Using fiber photometry recordings, we found that optogenetic stimulation of serotonergic axons in primary visual thalamus of awake mice suppressed ongoing and visually evoked calcium activity and glutamate release from RGC boutons. Two-photon calcium imaging revealed that serotonin axon stimulation suppressed RGC boutons that responded strongly to global changes in luminance more than those responding only to local visual stimuli, while the converse was true for suppression induced by increases in arousal. Converging evidence suggests that differential expression of the 5-HT1B receptor on RGC presynaptic terminals, but not differential density of nearby serotonin axons, may contribute to the selective serotonergic gating of specific visual information streams before they can activate thalamocortical neurons.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.