Evidence map›Paper›PMID 36584478›Full record

ArticleJournal of molecular and cellular cardiology2023

Myh6 promoter-driven Cre recombinase excises floxed DNA fragments in a subset of male germline cells.

Caroline Sheldon, Chase W Kessinger, Yan Sun, Maria I Kontaridis, Qianyi Ma, Saher Sue Hammoud, Zibei Gao, Hui Zhang, Zhiqiang Lin

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular and cellular cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Comparative analysis of two independent Myh6-Cre transgenic mouse lines.Journal of molecular and cellular cardiology plus · 2024
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Caroline SheldonMasonic Medical Research Institute, 2150 Bleecker Street, Utica, NY 13501, United States of America.
Chase W KessingerMasonic Medical Research Institute, 2150 Bleecker Street, Utica, NY 13501, United States of America.
Yan SunMasonic Medical Research Institute, 2150 Bleecker Street, Utica, NY 13501, United States of America.
Maria I KontaridisMasonic Medical Research Institute, 2150 Bleecker Street, Utica, NY 13501, United States of America; Department of Medicine, Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
Qianyi MaDepartment of Human Genetics, University of Michigan, Ann Arbor, MI, USA.
Saher Sue HammoudDepartment of Human Genetics, University of Michigan, Ann Arbor, MI, USA; Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA; Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, MI, USA; Department of Urology, University of Michigan, Ann Arbor, MI, USA.
Zibei GaoSchool of Life Science and Technology, ShanghaiTech University, 393 Middle Huaxia Road, Pudong, Shanghai 201210, China.
Hui ZhangSchool of Life Science and Technology, ShanghaiTech University, 393 Middle Huaxia Road, Pudong, Shanghai 201210, China.
Zhiqiang LinMasonic Medical Research Institute, 2150 Bleecker Street, Utica, NY 13501, United States of America. Electronic address: zlin@mmri.edu.
Masonic Medical Research Laboratory · USShanghaiTech University · CNUniversity of Michigan–Ann Arbor · USHarvard University · US

Funding

The Role of RhoA in the Molecular Pathogenesis of Heart DiseaseR01HL102368 · NHLBI · MASONIC MEDICAL RESEARCH LABORATORY, INC · PI KONTARIDIS, MARIA I · 2010 to 2021
$5.1M
YAP and IRF2BP2 regulation of cardiomyocyte innate immune responsesR01HL146810 · NHLBI · MASONIC MEDICAL RESEARCH LABORATORY, INC · PI Zhiqiang Lin · 2022 to 2026
$3.2M
NHLBI NIH HHS R01 HL102368NHLBI NIH HHS R01 HL146810
6 · The paper itself

Abstract

Myh6-Cre transgenic mouse line was known to express Cre recombinase only in the heart. Nevertheless, during breeding Myh6-Cre to Rosa26

Indexed as

Germ CellsIntegrasesAnimalsMaleMiceMice, TransgenicPromoter Regions, GeneticCre recombinaseIntegrasesCreGermline cellsMyh6 promotertdTom reporter

Identifiers

PMID36584478
PMCPMC9974737
OpenAlexW4313212773

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.