Evidence map›Paper›PMID 36584301›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Mechanism of PKCε regulation of cardiac GIRK channel gating.

Kirin D Gada, Mengmeng Chang, Aishwarya Chandrashekar, Leigh D Plant, Sami F Noujaim, Diomedes E Logothetis

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. PKC isoform-specific targeting of the phosphorylation site SerinePflugers Archiv : European journal of physiology · 2026
    Article
  2. Review
  3. G protein-gated inwardly rectifying KHistology and histopathology · 2025
    Review
  4. Angiotensin receptors and αPflugers Archiv : European journal of physiology · 2024
    Article
  5. The W101CInternational journal of molecular sciences · 2023
    Article
  6. PI(4,5)P2 regulates the gating of NaV1.4 channels.The Journal of general physiology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Kirin D GadaDepartment of Pharmaceutical Sciences, Bouvé College of Health Sciences and College of Science, Northeastern University, Boston, MA 02115.
Mengmeng ChangDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL 33602.
Aishwarya ChandrashekarDepartment of Pharmaceutical Sciences, Bouvé College of Health Sciences and College of Science, Northeastern University, Boston, MA 02115.
Leigh D PlantDepartment of Pharmaceutical Sciences, Bouvé College of Health Sciences and College of Science, Northeastern University, Boston, MA 02115.ORCID 0000-0002-1622-1655
Sami F NoujaimDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL 33602.
Diomedes E LogothetisDepartment of Pharmaceutical Sciences, Bouvé College of Health Sciences and College of Science, Northeastern University, Boston, MA 02115.ORCID 0000-0002-0576-884X
Northeastern University · USUniversity of South Florida · US

Funding

Structural Determinants of PIP2 RegulationR01HL059949 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI Leigh Daniel Plant · 1998 to 2026
$11.6M
Peptibodies As Novel Therapies in Atrial FibrillationR01HL163943 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI Sami Fouad Noujaim, MICHAEL N TENG · 2023 to 2026
$2.4M
SUMO-regulation of ion channels via PIP2R01HL144615 · NHLBI · NORTHEASTERN UNIVERSITY · PI PLANT, LEIGH DANIEL · 2019 to 2022
$1.6M
NHLBI NIH HHS R01 HL059949NHLBI NIH HHS R01 HL144615NHLBI NIH HHS R01 HL163943
6 · The paper itself

Abstract

G-protein-gated inwardly rectifying potassium (GIRK) channel activity is regulated by the membrane phospholipid, phosphatidylinositol-4,5-bisphosphate (PI 4,5P

Indexed as

Atrial FibrillationG Protein-Coupled Inwardly-Rectifying Potassium ChannelsAnimalsHeart AtriaHumansMiceMyocytes, CardiacProtein Kinase C-epsilonG Protein-Coupled Inwardly-Rectifying Potassium ChannelsProtein Kinase C-epsilonatrial fibrillationGIRK channelsion channelsphosphorylationprotein kinase C

Identifiers

PMID36584301
PMCPMC9910474
OpenAlexW4313410334

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.