Evidence map›Paper›PMID 36584202›Full record

ArticlePloS one2022

Rubella virus IgM and IgG antibodies with avidity in pregnant women and outcomes at a tertiary facility in Ghana.

Naa Baake Armah, Kwamena W Sagoe, Mercy Nuamah, Alfred E Yawson, Edmund T Nartey, Vera A Essuman, Nana-Akyaa Yao, Kenneth K Baidoo, Jemima Anowa Fynn, Derrick Tetteh and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Naa Baake ArmahDepartment of Obstetrics and Gynaecology, Korle Bu Teaching Hospital, Accra, Ghana.
Kwamena W SagoeDepartment of Medical Microbiology, University of Ghana Medical School, College of Health Sciences, University of Ghana, Legon, Ghana.ORCID 0000-0002-8891-8267
Mercy NuamahDepartment of Obstetrics and Gynaecology, Korle Bu Teaching Hospital, Accra, Ghana.
Alfred E YawsonDepartment of Community Health, University of Ghana Medical School, College of Health Sciences, University of Ghana, Legon, Ghana.
Edmund T NarteyCenter for Tropical Clinical Pharmacology and Therapeutics, University of Ghana Medical School, College of Health Sciences, University of Ghana, Legon, Ghana.
Vera A EssumanDepartment of Surgery, University of Ghana Medical School, University of Ghana, Accra, Ghana.
Nana-Akyaa YaoCardiothoracic Centre, Korle Bu Teaching Hospital, Accra, Ghana.
Kenneth K BaidooDepartment of Surgery, University of Ghana Medical School, University of Ghana, Accra, Ghana.
Jemima Anowa FynnDepartment of Surgery, University of Ghana Medical School, University of Ghana, Accra, Ghana.
Derrick TettehDepartment of Medical Microbiology, University of Ghana Medical School, College of Health Sciences, University of Ghana, Legon, Ghana.
Eva Gyamaa-YeboahDepartment of Obstetrics and Gynaecology, Korle Bu Teaching Hospital, Accra, Ghana.
Makafui SeshieDepartment of Medical Microbiology, University of Ghana Medical School, College of Health Sciences, University of Ghana, Legon, Ghana.
Isaac BoamahDepartment of Medical Microbiology, University of Ghana Medical School, College of Health Sciences, University of Ghana, Legon, Ghana.
Kobina NkyekyerDepartment of Obstetrics and Gynaecology, Korle Bu Teaching Hospital, Accra, Ghana.
University of Ghana · GHKorle Bu Teaching Hospital · GH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCongenital rubella syndrome (CRS) is a recognised cause of childhood deafness and blindness caused by the transplacental transmission of rubella virus during pregnancy. Women in the reproductive age group, and by extension their unborn babies may therefore be at increased risk. The prevalence of Rubella virus specific IgM and IgG antibodies, including IgG avidity, was determined in pregnant women attending the antenatal clinic at a Teaching Hospital in Ghana.

methodsOne hundred and forty-five women in their second and third trimesters of pregnancy from the outpatient clinic were recruited over a period of 2 months after written informed consent was obtained. Study participants completed a questionnaire and venous blood drawn for IgM, IgG, and avidity testing using SERION ELISA (SERION® Immunologics, Würzburg, Germany). Babies of mothers with positive or indeterminate IgM and low avidity IgG antibodies were offered specialist cardiological, ophthalmological or hearing assessment during follow up.

resultsOne hundred and twenty-eight (88.3%) had only IgG antibodies, 5 (3.4%) had IgM and IgG antibodies, while 12 (8.3%) had no antibodies. No patient had IgM antibodies alone. Ten women (6.9%) had indeterminate levels of IgM antibodies. Majority of the women had high avidity IgG antibodies, while 5 (3.4%) had low avidity antibodies. No patient had IgM with low avidity antibodies. There was no statistical association between socio-demographic factors and the presence of IgM, IgG (low or high avidity) antibodies. Of all the children followed, none had the clinical definition of CRS.

conclusionsConsistent with the World Health Organization elimination strategy for measles and rubella viruses, non-immune women in the reproductive age group should be vaccinated. The immunization programme should be expanded to include teenagers and adults. Though Congenital Rubella Syndrome was not detected, the risk still remains.

Indexed as

Pregnancy Complications, InfectiousRubellaAdolescentAdultAntibodies, ViralChildFemaleGhanaHumansImmunoglobulin GImmunoglobulin MPregnancyPregnant PeopleRubella virusAntibodies, ViralImmunoglobulin GImmunoglobulin M

Identifiers

PMID36584202
PMCPMC9803272
OpenAlexW4313307726

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.