Evidence map›Paper›PMID 36583726›Full record

ArticleeLife2022

Calcium dependence of both lobes of calmodulin is involved in binding to a cytoplasmic domain of SK channels.

David B Halling, Ashley E Philpo, Richard W Aldrich

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Small-conductance CaThe Journal of physiology · 2026
    Review
  2. Structural basis for the subtype-selective activation of KStructure (London, England : 1993) · 2026
    Article
  3. Andrology · 2025
    Review
  4. Frontiers in neuroscience · 2025
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

David B HallingDepartment of Neuroscience, The University of Texas at Austin, Austin, United States.ORCID 0000-0003-0921-8738
Ashley E PhilpoDepartment of Neuroscience, The University of Texas at Austin, Austin, United States.
Richard W AldrichDepartment of Neuroscience, The University of Texas at Austin, Austin, United States.ORCID 0000-0001-7254-5876
The University of Texas at Austin · US

Funding

Mechanisms of Calcium-Calmodulin Mediated Ion Channel GatingR01NS077821 · NINDS · UNIVERSITY OF TEXAS AT AUSTIN · PI ALDRICH, RICHARD · 2011 to 2021
$4.7M
Pore Gating Mechanisms of BK ChannelsR01GM127332 · NIGMS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI ALDRICH, RICHARD, HORRIGAN, FRANK T · 2018 to 2021
$1.7M
NINDS NIH HHS R01 NS077821
6 · The paper itself

Abstract

KCa2.1-3 Ca

Indexed as

CalciumCalmodulinCalcium, DietaryCalcium SignalingSmall-Conductance Calcium-Activated Potassium ChannelsTryptophanCalciumCalcium, DietaryCalmodulinSmall-Conductance Calcium-Activated Potassium ChannelsTryptophanbiochemistrycalciumcalmodulinchemical biologyE. coliHEKhumanion channel gatingKCa2.1molecular biophysicspotassium channelratstructural biology

Identifiers

PMID36583726
PMCPMC9803350
OpenAlexW4313357789

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.