Evidence map›Paper›PMID 36583573›Full record

ArticleGlia2023

Early microglial response, myelin deterioration and lethality in mice deficient for very long chain ceramide synthesis in oligodendrocytes.

Jonathan D Teo, Oana C Marian, Alanna G Spiteri, Madeline Nicholson, Huitong Song, Jasmine X Y Khor, Holly P McEwen, Anjie Ge, Monokesh K Sen, Laura Piccio and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Glia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
  2. Article
  3. Dyslipidemia is a metabolic hallmark of acute pain in sickle cell disease.medRxiv : the preprint server for health sciences · 2026
    Article
  4. GPIHBP1 on oligodendrocytes binds lipoprotein lipase within the human brain.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Review
  20. A novel HSPB1Prostaglandins & other lipid mediators · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 3 countries.

Jonathan D TeoCharles Perkins Centre and School of Medical Sciences, The University of Sydney, Camperdown, New South Wales, Australia.ORCID 0000-0003-3895-8663
Oana C MarianCharles Perkins Centre and School of Medical Sciences, The University of Sydney, Camperdown, New South Wales, Australia.ORCID 0000-0001-5629-7884
Alanna G SpiteriCharles Perkins Centre and School of Medical Sciences, The University of Sydney, Camperdown, New South Wales, Australia.ORCID 0000-0001-6787-6195
Madeline NicholsonDepartment of Anatomy and Physiology, The University of Melbourne, Parkville, Victoria, Australia.ORCID 0000-0002-4740-8658
Huitong SongCharles Perkins Centre and School of Medical Sciences, The University of Sydney, Camperdown, New South Wales, Australia.
Jasmine X Y KhorCharles Perkins Centre and School of Medical Sciences, The University of Sydney, Camperdown, New South Wales, Australia.ORCID 0000-0002-3214-2412
Holly P McEwenCharles Perkins Centre and School of Medical Sciences, The University of Sydney, Camperdown, New South Wales, Australia.ORCID 0000-0002-8233-1553
Anjie GeCharles Perkins Centre and School of Medical Sciences, The University of Sydney, Camperdown, New South Wales, Australia.ORCID 0000-0002-1027-2793
Monokesh K SenCharles Perkins Centre and School of Medical Sciences, The University of Sydney, Camperdown, New South Wales, Australia.ORCID 0000-0003-3988-9196
Laura PiccioCharles Perkins Centre and School of Medical Sciences, The University of Sydney, Camperdown, New South Wales, Australia.ORCID 0000-0002-8760-109X
Jessica L FletcherMenzies Institute for Medical Research, The University of Tasmania, Hobart, Tasmania, Australia.ORCID 0000-0003-2009-0798
Nicholas J C KingCharles Perkins Centre and School of Medical Sciences, The University of Sydney, Camperdown, New South Wales, Australia.ORCID 0000-0002-3877-9772
Simon S MurrayDepartment of Anatomy and Physiology, The University of Melbourne, Parkville, Victoria, Australia.ORCID 0000-0001-6671-192X
Jens C BrüningMax Planck Institute for Metabolism Research, Cologne, Germany.
Anthony S DonCharles Perkins Centre and School of Medical Sciences, The University of Sydney, Camperdown, New South Wales, Australia.ORCID 0000-0003-1655-1184
The University of Sydney · AUThe University of Melbourne · AUMax Planck Institute for Metabolism Research · DEUniversity of Tasmania · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The sphingolipids galactosylceramide (GalCer), sulfatide (ST) and sphingomyelin (SM) are essential for myelin stability and function. GalCer and ST are synthesized mostly from C22-C24 ceramides, generated by Ceramide Synthase 2 (CerS2). To clarify the requirement for C22-C24 sphingolipid synthesis in myelin biosynthesis and stability, we generated mice lacking CerS2 specifically in myelinating cells (CerS2

Indexed as

MicrogliaMyelin SheathAnimalsCeramidesMiceSphingolipidsCeramidesN-docosanoyl-16-methylheptadecasphing-4-enineSphingolipidsceramideCERS2demyelinationlipidmicrogliamyelinsphingolipid

Identifiers

PMID36583573
PMCPMC10952316
OpenAlexW4313311742

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.