Evidence map›Paper›PMID 36583545›Full record

ArticleBiochemistry2023

Contrasting Mechanisms of Aromatic and Aryl-Methyl Substituent Hydroxylation by the Rieske Monooxygenase Salicylate 5-Hydroxylase.

Melanie S Rogers, Adrian M Gordon, Todd M Rappe, Jason D Goodpaster, John D Lipscomb

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Melanie S RogersDepartment of Biochemistry, Molecular Biology, and Biophysics and Center for Metals in Biocatalysis, University of Minnesota, Minneapolis, Minnesota55455, United States.ORCID 0000-0002-2657-7065
Adrian M GordonDepartment of Chemistry, University of Minnesota, Minneapolis, Minnesota55455, United States.
Todd M RappeMinnesota NMR Center, University of Minnesota, Minneapolis, Minnesota55455, United States.
Jason D GoodpasterDepartment of Chemistry, University of Minnesota, Minneapolis, Minnesota55455, United States.ORCID 0000-0001-6461-4501
John D LipscombDepartment of Biochemistry, Molecular Biology, and Biophysics and Center for Metals in Biocatalysis, University of Minnesota, Minneapolis, Minnesota55455, United States.ORCID 0000-0002-8158-5594
University of Minnesota · US

Funding

Intermediates in O2 Activation by Oxygenases at Non-heme Iron CentersR35GM118030 · NIGMS · UNIVERSITY OF MINNESOTA · PI LIPSCOMB, JOHN D · 2016 to 2020
$2.7M
Console Upgrade for a 600 MHz NMR SpectrometerS10OD021536 · OD · UNIVERSITY OF MINNESOTA · PI VEGLIA, GIANLUIGI · 2016 to 2016
$850k
NIGMS NIH HHS R35 GM118030NIH HHS S10 OD021536
6 · The paper itself

Abstract

The hydroxylase component (S5HH) of salicylate-5-hydroxylase catalyzes C5 ring hydroxylation of salicylate but switches to methyl hydroxylation when a C5 methyl substituent is present. The use of

Indexed as

Ferric CompoundsMixed Function OxygenasesCatalysisFerrous CompoundsHydroxylationIronOxidation-ReductionSalicylatesFerric CompoundsFerrous CompoundsIronMixed Function OxygenasesSalicylatessalicylic acid 5-hydroxylase

Identifiers

PMID36583545
PMCPMC9854337
OpenAlexW4313299170

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.