ArticleeLife2022
Right inferior frontal gyrus damage is associated with impaired initiation of inhibitory control, but not its implementation.
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Psychotherapy and inhibitory control: Insights from fMRI research.Psychiatry and clinical neurosciences · 2026Pooled it
- The Neural Correlates of Response Inhibition With and Without Conflict in ADHD: An Activation Likelihood Estimation Meta-Analysis.The European journal of neuroscience · 2025Pooled it
- Effects of single-session transcranial direct current stimulation on response inhibition in stop-signal task performance: A meta-analysis and systematic review.General psychiatry · 2026Article
- Distinct temporal patterns of beta bursts differentiate successful and failed movement cancellation.iScience · 2026Article
- Neural Correlates of Inhibitory Control in Impulsivity Traits in Non-Ecological Human-Computer Tasks: An ALE Meta-Analysis.Brain sciences · 2026Review
- A cortico-subthalamic circuit rapidly engages and releases inhibition of specific movements depending on the environmental context.PLoS biology · 2026Article
- Article
- Cortico-basal ganglia dynamics of global and selective response inhibition in humans.bioRxiv : the preprint server for biology · 2026Article
- Unraveling the mystery of stuttering: clinical and physiological insights into its manifestation.Frontiers in human neuroscience · 2026Article
- Neural signatures and personalized neuromodulation in a subject experiencing context-dependent inhibitory control deficits.NeuroImage · 2025Article
- Parietal cortex is recruited by frontal and cingulate areas to support action monitoring and updating during stopping.NeuroImage · 2025Article
- Withstand Context: Standing Posture Improves Contextual Cueing in Challenging Visual Search.Psychophysiology · 2025Article
- Brain mechanisms underlying the inhibitory control of thought.Nature reviews. Neuroscience · 2025Review
- Frontal and Parietal Activities Associated With Different Inhibitory Processes in a Stroop-Matching/Stop-Signal Task: A Channel-Wise fNIRS Study.Psychophysiology · 2025Article
- Hierarchical Organization of Bilateral Prefrontal-Basal Ganglia Circuits for Response Inhibition Control.Human brain mapping · 2025Article
- Article
- Common and Unique Neurophysiological Processes That Support the Stopping and Revising of Actions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Does the stop-signal P3 reflect inhibitory control?Cortex; a journal devoted to the study of the nervous system and behavior · 2025Review
- Exploring the relationship between physical activity and Inhibitory Function in College Students with depressive symptoms through EEG.Scientific reports · 2025Article
- rTMS-induced neuroimaging changes measured with structural and functional MRI in autism.Frontiers in neuroscience · 2025Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Inhibitory control is one of the most important control functions in the human brain. Much of our understanding of its neural basis comes from seminal work showing that lesions to the right inferior frontal gyrus (rIFG) increase stop-signal reaction time (SSRT), a latent variable that expresses the speed of inhibitory control. However, recent work has identified substantial limitations of the SSRT method. Notably, SSRT is confounded by trigger failures: stop-signal trials in which inhibitory control was never initiated. Such trials inflate SSRT, but are typically indicative of attentional, rather than inhibitory deficits. Here, we used hierarchical Bayesian modeling to identify stop-signal trigger failures in human rIFG lesion patients, non-rIFG lesion patients, and healthy comparisons. Furthermore, we measured scalp-EEG to detect β-bursts, a neurophysiological index of inhibitory control. rIFG lesion patients showed a more than fivefold increase in trigger failure trials and did not exhibit the typical increase of stop-related frontal β-bursts. However, on trials in which such β-bursts did occur, rIFG patients showed the typical subsequent upregulation of β over sensorimotor areas, indicating that their ability to implement inhibitory control, once triggered, remains intact. These findings suggest that the role of rIFG in inhibitory control has to be fundamentally reinterpreted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.