ArticleJournal of drug assessment2023
Treatment and comorbidity burden among people living with HIV: a review of systematic literature reviews.
Article in Journal of drug assessment, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- Never Too Late: A Case Report of Severe Fanconi Syndrome Developing After More than a Decade of Silent Tenofovir Disoproxil Fumarate Exposure.Reports (MDPI) · 2026Article
- Comorbidities, health-related quality of life and its associated factors among people living with HIV/AIDS in Gandaki Province of Nepal.BMC public health · 2026Article
- Cost of implementing tailored motivational interviewing training in youth HIV clinics.BMC health services research · 2026Observational
- Healthcare Resource Consumption and Related Costs of People Living with HIV and Antiviral Treatment: A Retrospective Observational Study in Italy.Diseases (Basel, Switzerland) · 2026Article
- Evaluating the relationship between adherence to antiretroviral therapy and health-related quality of life among people living with HIV/AIDS in Northwestern Nigeria.BMC public health · 2026Article
- Projected Increases in Older People With HIV in the United States Through 2040.Open forum infectious diseases · 2025Article
- Network analysis of comorbid mental health disorders among people with HIV in the All of Us Research Program.Research square · 2025Article
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- Updates on bone health in people living with HIV: global impact, prediction tools, and treatment.Current opinion in HIV and AIDS · 2025Review
- Experiences of Older People Living with Human Immunodeficiency Virus Comorbidity Attending Coordinated Healthcare Services.Annals of geriatric medicine and research · 2025Article
- Correlates of internalized stigma and antiretroviral therapy adherence among people living with HIV in the Volta region of Ghana.BMC public health · 2025Article
- Resource Use and Cost Associated With Cardiovascular, Renal, Bone, and Neuropsychiatric Comorbidities in People With HIV in Spain.Journal of health economics and outcomes research · 2025Article
- Beyond Viral Suppression: Navigating Structural Barriers, Aging and Frailty, Drug Resistance, Therapeutic Innovations, and Reproductive Health Challenges in the Global HIV/AIDS Epidemic.Journal of AIDS and HIV treatment · 2025Article
- Metabolic, Mitochondrial, and Inflammatory Effects of Efavirenz, Emtricitabine, and Tenofovir Disoproxil Fumarate in Asymptomatic Antiretroviral-Naïve People with HIV.International journal of molecular sciences · 2024Article
- Relationship between adherence to bictegravir/emtricitabine/tenofovir alafenamide fumarate and clinical outcomes in people with HIV in Japan: a claims database analysis.Scientific reports · 2024Article
- Stigma and mental health among people living with HIV across the COVID-19 pandemic: a cross-sectional study.BMC infectious diseases · 2024Article
- Association Between TyG Index, Liver Steatosis and Immunosenescence in People Living with HIV.Infection and drug resistance · 2024Article
- Coping strategies, challenges and potential interventions among adult patients with HIV and mental illness comorbidity in southwestern Uganda.Global public health · 2024Article
- Redefining HIV care: a path toward sustainability post-UNAIDS 95-95-95 targets.Frontiers in public health · 2023Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: As the human immunodeficiency virus (HIV) treatment landscape continues to evolve, the prolonged life expectancy and long-term exposure to antiretroviral drugs have modified the burden associated with living with HIV. Objective: To better understand the current treatment and comorbidity burden in people living with HIV (PLWH). Methods: Peer-reviewed systematic literature reviews (SLRs) between 2017 and 2020 that included US studies and examined drug adherence/pill burden, resistance burden, or comorbidities in PLWH were identified. Methods and findings were extracted for the overall studies and examined in the subset of US studies. Results: Among 665 publications identified, 47 met the inclusion criteria (drug adherence/pill burden: 5; resistance: 3; comorbidities: 40). While antiretroviral drug adherence levels varied across SLRs, single-tablet regimens (STR) were associated with higher adherence versus multiple-tablet regimens. STRs were also associated with lower risk of treatment discontinuation, higher cost-effectiveness, and lower risk of hospitalization. Longer survival resulted in a high comorbidity burden, with non-AIDS causes accounting for 47% of deaths among PLWH in the US. HIV doubled the risk of cardiovascular disease and was associated with other health problems, including bone and muscle diseases, depression, and cancers. Several antiretroviral regimens were associated with chronic diseases, including cardiometabolic conditions. Lifetime HIV costs are substantially increasing, driven by antiretroviral, adverse event, and comorbidity treatment costs cumulated due to longer survival times. Conclusions: There is a considerable burden associated with HIV and antiretroviral treatment, highlighting the benefits of less complex and safer regimens, and the unmet need for effective preventative interventions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.