Initial Experience With Trans-anal Minimally Invasive Surgery (TAMIS) for Rectal Polyps and Early Colorectal Cancers at Cumberland Infirmary, Carlisle.

introductionBowel cancer is the fourth most common type of cancer in the United Kingdom in 2019. Total mesorectal excision is the standard procedure for the removal of rectal tumors, however, it comes with serious side effects. Therefore, less invasive procedures and sphincter preservation techniques have been developed, like conventional trans-anal excision, and trans-anal endoscopic microsurgery (TEM). In 2010, trans-anal minimally invasive surgery (TAMIS) was introduced as an alternative to TEM, which offers the same benefits as TEM but at a lower cost and without the need for specialized instrumentation. This study aims to assess the practicability and safety of this technique and to report its findings.  Methods: Retrospective data of all patients who underwent TAMIS at Cumberland Infirmary (Carlisle, UK) from July 2017 to July 2022 for large benign rectal polyps or early rectal cancer were collected. Variables collected included patients' age, gender, number of procedures per year, perioperative outcome, and histopathology outcome. The SPSS version 21 (IBM Corp., Armonk, NY, USA) was used for both descriptive and inferential analyses of the data.

resultsDuring a five-year period, 42 patients underwent TAMIS at Cumberland Infirmary. The primary indication for TAMIS was distal rectal lesions, large rectal polyps up to 120 mm, and early rectal cancer (T1). The median age of the assessed patients at the time of surgery was 71 years with 64.29% (27) male and 35.71% (15) female. The mean operating time was 123 minutes (range 45 to 240 minutes). The surgical and pathological outcome included a mean polyp size of 6 cm (+/- 0.8 cm), a rate of specimen fragmentation at 19.04% (n=8), and a rate of positive margins at 04.76% (n=2), whereas histology of 73.81% (n=31) was tubulovillous adenoma and 11.91% (n=5) was adenocarcinoma. There was no 30-day postoperative mortality, however, the 30-day re-operation rate was 02.39% (n=1) and the recurrence rate which needed further intervention was 26.19% (n=11).

conclusionOur findings suggest that TAMIS produces positive results. The size of the lesions removed, and the effect of an early learning curve are reflected in the rate of specimen fragmentation and polyp recurrence. Nonetheless, TAMIS is a safe and effective alternative to total mesorectal excision for certain types of rectal lesions and should be used for more proximal and complex rectal lesions.