Evidence map›Paper›PMID 36582440›Full record

ReviewComputational and structural biotechnology journal2023

Histone variants and chromatin structure, update of advances.

Vladyslava Sokolova, Shayan Sarkar, Dongyan Tan

Abstract readReview
In one paragraph

Review in Computational and structural biotechnology journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Vladyslava SokolovaDepartment of Pharmacological Sciences, Stony Brook University, Stony Brook, New York 11794, USA.
Shayan SarkarDepartment of Pharmacological Sciences, Stony Brook University, Stony Brook, New York 11794, USA.
Dongyan TanDepartment of Pharmacological Sciences, Stony Brook University, Stony Brook, New York 11794, USA.

Funding

Dynamics and Regulation of Chromatin in DNA MetabolismR35GM133611 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI TAN, DONGYAN · 2019 to 2023
$2.1M
NIGMS NIH HHS R35 GM133611
6 · The paper itself

Abstract

Histone proteins are highly conserved among all eukaryotes. They have two important functions in the cell: to package the genomic DNA and to regulate gene accessibility. Fundamental to these functions is the ability of histone proteins to interact with DNA and to form the nucleoprotein complex called chromatin. One of the mechanisms the cells use to regulate chromatin and gene expression is through replacing canonical histones with their variants at specific loci to achieve functional consequence. Recent cryo-electron microscope (cryo-EM) studies of chromatin containing histone variants reveal new details that shed light on how variant-specific features influence the structures and functions of chromatin. In this article, we review the current state of knowledge on histone variants biochemistry and discuss the implication of these new structural information on histone variant biology and their functions in transcription.

Indexed as

ChromatinElectron microscopyHistone variantNucleosomeProtein structure

Identifiers

PMID36582440
PMCPMC9764139

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.