Evidence map›Paper›PMID 36582384›Full record

ArticleFrontiers in public health2022

A comparative study of virus nucleic acid re-positive and non-re-positive patients infected with SARS-CoV-2 Delta variant strain in the Ningxia Hui Autonomous Region.

Jing Wang, Shu-Xiang Zhang, Jian-Rong Na, Li-Ling Zhang, Yin-Hao Zhang, Jiao-Jiao Chu, Lei Guo, Mei Yan, Yu-Ting Li, Wei Zhou

Abstract read
In one paragraph

Article in Frontiers in public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jing WangClinical Medical College, Ningxia Medical University, Yinchuan, China.
Shu-Xiang ZhangDepartment of Respiratory and Critical Care Medicine, Ningxia Medical University General Hospital, Yinchuan, China.
Jian-Rong NaDepartment of Respiratory and Critical Care Medicine, Ningxia Medical University General Hospital, Yinchuan, China.
Li-Ling ZhangDepartment of Medical Education, Fourth People's Hospital of the Ningxia Hui Autonomous Region, Yinchuan, China.
Yin-Hao ZhangNingxia Center for Disease Control, Yinchuan, China.
Jiao-Jiao ChuDepartment of Respiratory and Critical Care Medicine, Ningxia Medical University General Hospital, Yinchuan, China.
Lei GuoDepartment of Comprehensive Internal Medicine, Fourth People's Hospital of the Ningxia Hui Autonomous Region, Yinchuan, China.
Mei YanDepartment of Respiratory and Critical Care Medicine, Ningxia Medical University General Hospital, Yinchuan, China.
Yu-Ting LiClinical Medical College, Ningxia Medical University, Yinchuan, China.
Wei ZhouDepartment of Respiratory and Critical Care Medicine, Ningxia Medical University General Hospital, Yinchuan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This study aimed to provide a basis for epidemic prevention and control measures as well as the management of re-positive personnel by analyzing and summarizing the characteristics of re-positive patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta variant infections discharged from a hospital in the Ningxia Hui Autonomous Region in 2021. Methods: This case-control study included a total of 45 patients with Delta variant infections diagnosed in the Fourth People's Hospital of the Ningxia Hui Autonomous Region between October 17 and November 28, 2021. Based on the nucleic acid test results post-discharge, the patients were dichotomized into re-positive and non-re-positive groups. Based on the time of the first re-positive test, the re-positive group was further divided into <7 and ≥7 days groups to compare their clinical characteristics and explore the possible influencing factors of this re-positivity. Results: Of the 45 total patients, 16 were re-positive (re-positivity rate: 35.6%), including four patients who were re-positive after 2 weeks (re-positivity rate: 8.8%). The median time of the first re-positive after discharge was 7 days (IQR: 14-3). The re-positive group was younger than the non-re-positive group (35 vs. 53, Conclusions: In conclusion, this study found that: (1) The re-positivity rate of SARS-CoV-2 Delta variant infection in this group was 35.6%, while the re-positivity rate was the same as that of the original strain 2 weeks after discharge (8.0%). (2) Young people, patients who did not use antiviral therapy or had low IgG antibody levels at discharge were more likely to have re-positive. And the CT value of nucleic acid at the time of initial infection was higher in re-positive group. We speculated that the higher the CT value of nucleic acid at the time of initial infection, the longer the intermittent shedding time of the virus. (3) Re-positive patients were asymptomatic. The median CT value of nucleic acid was > 35 at the re-positive time, and the close contacts were not detected as positive. The overall transmission risk of re-positive patients is low.

Indexed as

COVID-19Nucleic AcidsAdolescentAftercareAntiviral AgentsCase-Control StudiesCOVID-19 VaccinesHumansImmunoglobulin GPatient DischargeSARS-CoV-2Antiviral AgentsCOVID-19 VaccinesImmunoglobulin GNucleic Acidsantibody levelCOVID-19 vaccineDelta variant infectionvirus nucleic acid CT valuevirus nucleic acid re-positive

Identifiers

PMID36582384
PMCPMC9792667

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.